TY - JOUR

T1 - The bioavailability, metabolism and microbial modulation of curcumin-loaded nanodelivery systems

AU - Chang, Ruxin

AU - Chen, Liran

AU - Qamar, Muhammad

AU - Wen, Yanjun

AU - Li, Linzheng

AU - Zhang, Jiayin

AU - Li, Xing

AU - Assadpour, Elham

AU - Esatbeyoglu, Tuba

AU - Kharazmi, Mohammad Saeed

AU - Li, Yuan

AU - Jafari, Seid Mahdi

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (NSFC 31772014 , 31972202 ) and Henan Zhongda Hengyuan Biotechnology Company . The Chinese Ministry of Science and Technology “the Belt and Road” Innovative Talent Exchange Foreign Expert Project (Grant Number DL2021003001 and DL2021014003L ) is also acknowledged.

PY - 2023/8

Y1 - 2023/8

N2 - Curcumin (Cur), the major bioactive component of turmeric (Curcuma longa) possesses many health benefits. However, low solubility, stability and bioavailability restricts its applications in food. Recently, nanocarriers such as complex coacervates, nanocapsules, liposomes, nanoparticles, nanomicelles, have been used as novel strategies to solve these problems. In this review, we have focused on the delivery systems responsive to the environmental stimuli such as pH-responsive, enzyme-responsive, targeted-to-specific cells or tissues, mucus-penetrating and mucoadhesive carriers. Besides, the metabolites and their biodistribution of Cur and Cur delivery systems are discussed. Most importantly, the interaction between Cur and their carriers with gut microbiota and their effects of modulating the gut health synergistically were discussed comprehensively. In the end, the biocompatibility of Cur delivery systems and the feasibility of their application in food industry is discussed. This review provided a comprehensive review of Cur nanodelivery systems, the health impacts of Cur nanocarriers and an insight into the application of Cur nanocarriers in food industry.

AB - Curcumin (Cur), the major bioactive component of turmeric (Curcuma longa) possesses many health benefits. However, low solubility, stability and bioavailability restricts its applications in food. Recently, nanocarriers such as complex coacervates, nanocapsules, liposomes, nanoparticles, nanomicelles, have been used as novel strategies to solve these problems. In this review, we have focused on the delivery systems responsive to the environmental stimuli such as pH-responsive, enzyme-responsive, targeted-to-specific cells or tissues, mucus-penetrating and mucoadhesive carriers. Besides, the metabolites and their biodistribution of Cur and Cur delivery systems are discussed. Most importantly, the interaction between Cur and their carriers with gut microbiota and their effects of modulating the gut health synergistically were discussed comprehensively. In the end, the biocompatibility of Cur delivery systems and the feasibility of their application in food industry is discussed. This review provided a comprehensive review of Cur nanodelivery systems, the health impacts of Cur nanocarriers and an insight into the application of Cur nanocarriers in food industry.

KW - Bioavailability

KW - Curcumin

KW - Encapsulation

KW - Gastrointestinal digestion

KW - Nanocarriers

UR - http://www.scopus.com/inward/record.url?scp=85161345237&partnerID=8YFLogxK

U2 - 10.1016/j.cis.2023.102933

DO - 10.1016/j.cis.2023.102933

M3 - Review article

C2 - 37301064

VL - 318

JO - Advances in Colloid and Interface Science

JF - Advances in Colloid and Interface Science

SN - 0001-8686

M1 - 102933

ER -