TALENoffer: genome-wide TALEN off-target prediction

Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review

Autoren

  • Jan Grau
  • Jens Boch
  • Stefan Posch

Externe Organisationen

  • Martin-Luther-Universität Halle-Wittenberg
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Seiten (von - bis)2931-2932
Seitenumfang2
FachzeitschriftBioinformatics
Jahrgang29
Ausgabenummer22
PublikationsstatusVeröffentlicht - 15 Nov. 2013
Extern publiziertJa

Abstract

Summary: Transcription activator-like effector nucleases (TALENs) have become an accepted tool for targetedmutagenesis, but undesired off-targets remain an important issue. We present TALENoffer, a novel tool for the genome-wide prediction of TALENoff-targets.We showthat TALENoffer successfully predicts known off-targets of engineered TALENs and yields a competitive runtime, scanning completemammalian genomes within a few minutes.

ASJC Scopus Sachgebiete

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TALENoffer: genome-wide TALEN off-target prediction. / Grau, Jan; Boch, Jens; Posch, Stefan.
in: Bioinformatics, Jahrgang 29, Nr. 22, 15.11.2013, S. 2931-2932.

Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review

Grau J, Boch J, Posch S. TALENoffer: genome-wide TALEN off-target prediction. Bioinformatics. 2013 Nov 15;29(22):2931-2932. doi: 10.1093/bioinformatics/btt501
Grau, Jan ; Boch, Jens ; Posch, Stefan. / TALENoffer: genome-wide TALEN off-target prediction. in: Bioinformatics. 2013 ; Jahrgang 29, Nr. 22. S. 2931-2932.
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