Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1108-1110 |
| Seitenumfang | 3 |
| Fachzeitschrift | SYNLETT |
| Ausgabenummer | 10 |
| Publikationsstatus | Veröffentlicht - Okt. 1998 |
Abstract
The synthesis of the C7-C17 segment of epothilones employing a ring closing metathesis is described. Our approach utilizes the stereoselective methylation of the 10-membered lactone, generated by ring closing metathesis, for introducing the methyl group at C8 and provides an efficient access to strained epothilone derivatives, as well as to the C7-C17 segment of epothilones.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Organische Chemie
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in: SYNLETT, Nr. 10, 10.1998, S. 1108-1110.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Synthesis of the C7-C17 segment of epothilones by a 10-membered ring closing metathesis reaction
AU - Gerlach, Kai
AU - Quitschalle, Monika
AU - Kalesse, Markus
PY - 1998/10
Y1 - 1998/10
N2 - The synthesis of the C7-C17 segment of epothilones employing a ring closing metathesis is described. Our approach utilizes the stereoselective methylation of the 10-membered lactone, generated by ring closing metathesis, for introducing the methyl group at C8 and provides an efficient access to strained epothilone derivatives, as well as to the C7-C17 segment of epothilones.
AB - The synthesis of the C7-C17 segment of epothilones employing a ring closing metathesis is described. Our approach utilizes the stereoselective methylation of the 10-membered lactone, generated by ring closing metathesis, for introducing the methyl group at C8 and provides an efficient access to strained epothilone derivatives, as well as to the C7-C17 segment of epothilones.
UR - http://www.scopus.com/inward/record.url?scp=0001897541&partnerID=8YFLogxK
U2 - 10.1055/s-1998-1870
DO - 10.1055/s-1998-1870
M3 - Article
AN - SCOPUS:0001897541
SP - 1108
EP - 1110
JO - SYNLETT
JF - SYNLETT
SN - 0936-5214
IS - 10
ER -