Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 648-656 |
| Seitenumfang | 9 |
| Fachzeitschrift | European Journal of Organic Chemistry |
| Jahrgang | 2018 |
| Ausgabenummer | 5 |
| Publikationsstatus | Veröffentlicht - 28 Dez. 2017 |
Abstract
The synthesis of the aglycon of disciformycin, a new secondary metabolite from Pyxidicoccus fallax, is reported. The disciformycins are highly potent antibiotics including inhibitory activity towards methicillin- and vancomycin-resistant Staphylococcus aureus. The stereocontrolled installation of the olefinic double bonds at C2–C3/C3–C4 and C12–C13, respectively, as well as the orthogonal differentiation of the oxy functionalities turned out to be key challenges of our approach.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Physikalische und Theoretische Chemie
- Chemie (insg.)
- Organische Chemie
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in: European Journal of Organic Chemistry, Jahrgang 2018, Nr. 5, 28.12.2017, S. 648-656.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Synthesis of the Aglycon of the Antibiotic Disciformycin
AU - Wolling, Michael
AU - Kirschning, Andreas
PY - 2017/12/28
Y1 - 2017/12/28
N2 - The synthesis of the aglycon of disciformycin, a new secondary metabolite from Pyxidicoccus fallax, is reported. The disciformycins are highly potent antibiotics including inhibitory activity towards methicillin- and vancomycin-resistant Staphylococcus aureus. The stereocontrolled installation of the olefinic double bonds at C2–C3/C3–C4 and C12–C13, respectively, as well as the orthogonal differentiation of the oxy functionalities turned out to be key challenges of our approach.
AB - The synthesis of the aglycon of disciformycin, a new secondary metabolite from Pyxidicoccus fallax, is reported. The disciformycins are highly potent antibiotics including inhibitory activity towards methicillin- and vancomycin-resistant Staphylococcus aureus. The stereocontrolled installation of the olefinic double bonds at C2–C3/C3–C4 and C12–C13, respectively, as well as the orthogonal differentiation of the oxy functionalities turned out to be key challenges of our approach.
KW - Antibiotics
KW - Disciformycin
KW - Natural products
KW - Polyketides
UR - http://www.scopus.com/inward/record.url?scp=85041414202&partnerID=8YFLogxK
U2 - 10.1002/ejoc.201701639
DO - 10.1002/ejoc.201701639
M3 - Article
AN - SCOPUS:85041414202
VL - 2018
SP - 648
EP - 656
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
SN - 1434-193X
IS - 5
ER -