Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1028-1033 |
| Seitenumfang | 6 |
| Fachzeitschrift | Macromolecular Bioscience |
| Jahrgang | 10 |
| Ausgabenummer | 9 |
| Publikationsstatus | Veröffentlicht - 2 Juli 2010 |
Abstract
In this paper we report the first synthesis of novel polysialic acid derivatives which is initiated by treatment of polysialic acid with EDC-HCl to yield the inter-residual d-lactone. Subsequent reaction with amines or hydrazine gives the corresponding polysialic acid amides and hydrazide. Alkylation of the tetrabutylammonium salt of polysialic acid yields polysialic acid esters. In contrast a variety of N-derivatives of polysialic acid can be prepared starting from deacetylated polysialic acid. The N-derivatives prepared in this communication can be used for the Cu-catalyzed as well as Cu-free "click" chemistry. (Chemical Equation Presented).
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biotechnologie
- Chemische Verfahrenstechnik (insg.)
- Bioengineering
- Werkstoffwissenschaften (insg.)
- Biomaterialien
- Werkstoffwissenschaften (insg.)
- Polymere und Kunststoffe
- Werkstoffwissenschaften (insg.)
- Werkstoffchemie
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in: Macromolecular Bioscience, Jahrgang 10, Nr. 9, 02.07.2010, S. 1028-1033.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Synthesis of new polysialic acid derivatives
AU - Su, Yi
AU - Kasper, Cornelia
AU - Kirschning, Andreas
AU - Dräger, Gerald
AU - Berski, Silke
PY - 2010/7/2
Y1 - 2010/7/2
N2 - In this paper we report the first synthesis of novel polysialic acid derivatives which is initiated by treatment of polysialic acid with EDC-HCl to yield the inter-residual d-lactone. Subsequent reaction with amines or hydrazine gives the corresponding polysialic acid amides and hydrazide. Alkylation of the tetrabutylammonium salt of polysialic acid yields polysialic acid esters. In contrast a variety of N-derivatives of polysialic acid can be prepared starting from deacetylated polysialic acid. The N-derivatives prepared in this communication can be used for the Cu-catalyzed as well as Cu-free "click" chemistry. (Chemical Equation Presented).
AB - In this paper we report the first synthesis of novel polysialic acid derivatives which is initiated by treatment of polysialic acid with EDC-HCl to yield the inter-residual d-lactone. Subsequent reaction with amines or hydrazine gives the corresponding polysialic acid amides and hydrazide. Alkylation of the tetrabutylammonium salt of polysialic acid yields polysialic acid esters. In contrast a variety of N-derivatives of polysialic acid can be prepared starting from deacetylated polysialic acid. The N-derivatives prepared in this communication can be used for the Cu-catalyzed as well as Cu-free "click" chemistry. (Chemical Equation Presented).
KW - Biopolymers
KW - Click chemistry
KW - Polysaccharides
KW - Polysialic acid
KW - Synthesis
UR - http://www.scopus.com/inward/record.url?scp=77956646145&partnerID=8YFLogxK
U2 - 10.1002/mabi.201000094
DO - 10.1002/mabi.201000094
M3 - Article
C2 - 20602419
AN - SCOPUS:77956646145
VL - 10
SP - 1028
EP - 1033
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
SN - 1616-5187
IS - 9
ER -