Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 4539-4542 |
| Seitenumfang | 4 |
| Fachzeitschrift | Chemical communications |
| Jahrgang | 56 |
| Ausgabenummer | 33 |
| Frühes Online-Datum | 17 März 2020 |
| Publikationsstatus | Veröffentlicht - 28 Apr. 2020 |
| Extern publiziert | Ja |
Abstract
Mixed 2′-F-riboguanosine and 2′-F-arabinoguanosine disubstitutions of a hybrid-type G-quadruplex are found to induce a refolding into two alternative structures with different types of V-loops upon positional exchange of the two G analogs. While conformational preferences of the incorporated G surrogates fail to fully account for the observed rearrangements, additional hydrogen bonds with a fluorine acceptor are suggested to be critical determinants of the two distinct V-loop conformers imposing different tetrad polarities.
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in: Chemical communications, Jahrgang 56, Nr. 33, 28.04.2020, S. 4539-4542.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Switching the type of V-loop in sugar-modified G-quadruplexes through altered fluorine interactions
AU - Haase, Linn
AU - Weisz, Klaus
N1 - Funding Information: We thank the Deutsche Forschungsgemeinschaft for financial support (grant no. WE 1933/15-1).
PY - 2020/4/28
Y1 - 2020/4/28
N2 - Mixed 2′-F-riboguanosine and 2′-F-arabinoguanosine disubstitutions of a hybrid-type G-quadruplex are found to induce a refolding into two alternative structures with different types of V-loops upon positional exchange of the two G analogs. While conformational preferences of the incorporated G surrogates fail to fully account for the observed rearrangements, additional hydrogen bonds with a fluorine acceptor are suggested to be critical determinants of the two distinct V-loop conformers imposing different tetrad polarities.
AB - Mixed 2′-F-riboguanosine and 2′-F-arabinoguanosine disubstitutions of a hybrid-type G-quadruplex are found to induce a refolding into two alternative structures with different types of V-loops upon positional exchange of the two G analogs. While conformational preferences of the incorporated G surrogates fail to fully account for the observed rearrangements, additional hydrogen bonds with a fluorine acceptor are suggested to be critical determinants of the two distinct V-loop conformers imposing different tetrad polarities.
UR - http://www.scopus.com/inward/record.url?scp=85084028153&partnerID=8YFLogxK
U2 - 10.1039/d0cc01285h
DO - 10.1039/d0cc01285h
M3 - Article
VL - 56
SP - 4539
EP - 4542
JO - Chemical communications
JF - Chemical communications
SN - 0022-4936
IS - 33
ER -