Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 3061-3066 |
| Seitenumfang | 6 |
| Fachzeitschrift | Synthesis |
| Ausgabenummer | 18 |
| Publikationsstatus | Veröffentlicht - 2009 |
Abstract
The aldol reaction is one of the most powerful and versatile methods in polyketide synthesis. Nevertheless, the subtle directing effects remain very often obscure and impede complex natural products syntheses. Here, we report studies on the pivotal aldol coupling employed in the spirangien synthesis. We identified conditions for the stereoselective formation of both stereoisomers in the C22-C23 aldol juncture of spirangien.
ASJC Scopus Sachgebiete
- Chemische Verfahrenstechnik (insg.)
- Katalyse
- Chemie (insg.)
- Organische Chemie
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in: Synthesis, Nr. 18, 2009, S. 3061-3066.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Studies on the C22-C23 aldol coupling of spirangien
AU - Lorenz, Michael
AU - Bluhm, Nadine
AU - Kalesse, Markus
PY - 2009
Y1 - 2009
N2 - The aldol reaction is one of the most powerful and versatile methods in polyketide synthesis. Nevertheless, the subtle directing effects remain very often obscure and impede complex natural products syntheses. Here, we report studies on the pivotal aldol coupling employed in the spirangien synthesis. We identified conditions for the stereoselective formation of both stereoisomers in the C22-C23 aldol juncture of spirangien.
AB - The aldol reaction is one of the most powerful and versatile methods in polyketide synthesis. Nevertheless, the subtle directing effects remain very often obscure and impede complex natural products syntheses. Here, we report studies on the pivotal aldol coupling employed in the spirangien synthesis. We identified conditions for the stereoselective formation of both stereoisomers in the C22-C23 aldol juncture of spirangien.
KW - 1,4-induction
KW - Aldol reaction
KW - Cornforth model
KW - Felkin product
KW - Methyl ketone
KW - Natural products
UR - http://www.scopus.com/inward/record.url?scp=70449371845&partnerID=8YFLogxK
U2 - 10.1055/s-0029-1216918
DO - 10.1055/s-0029-1216918
M3 - Article
AN - SCOPUS:70449371845
SP - 3061
EP - 3066
JO - Synthesis
JF - Synthesis
SN - 0039-7881
IS - 18
ER -