Stereotactic radiosurgery for the treatment of brain metastases

Publikation: Beitrag in FachzeitschriftÜbersichtsarbeitForschungPeer-Review

Autoren

  • Falk Müller-Riemenschneider
  • Angelina Bockelbrink
  • Iris Ernst
  • Christoph Schwarzbach
  • Christoph Vauth
  • J. Matthias Graf von der Schulenburg
  • Stefan N. Willich

Externe Organisationen

  • Westfälische Wilhelms-Universität Münster (WWU)
  • Charité - Universitätsmedizin Berlin
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Details

OriginalspracheEnglisch
Seiten (von - bis)67-74
Seitenumfang8
FachzeitschriftRadiotherapy and Oncology
Jahrgang91
Ausgabenummer1
Frühes Online-Datum8 Jan. 2009
PublikationsstatusVeröffentlicht - Apr. 2009

Abstract

Background: The objective of this systematic review was to summarise the current evidence concerning radiosurgical treatment (SRS) of newly diagnosed brain metastasis and to compare SRS as a single or additional treatment to treatment alternatives with regard to medical effectiveness and safety. Methods: A structured search of electronic databases was performed to identify relevant publications from 2002 through 2007. Studies targeting patients with brain metastases were included. Standardised quality assessment and data extraction were performed. Results: Of 1496 publications, 16 studies were included. The mean survival in most studies was less than 12 months. There was evidence that SRS plus WBRT was associated with improved local tumour control and neurological functioning compared to either treatment alone. Only in patients with single metastasis, this resulted in improved survival. There was inconclusive evidence when comparing SRS to WBRT, Neurosurgery (NS) or Hypofractionated Radiotherapy (HCSRT). The Quality of life (Qol) was not investigated. Conclusion: SRS plus WBRT was associated with improved local tumour control and neurological functioning compared to either treatment alone. Only in certain patients, this resulted in improved survival. Methodologically rigorous studies are therefore warranted to investigate further treatment options, and in view of the poor prognosis, to investigate Qol and neurological functioning.

ASJC Scopus Sachgebiete

Zitieren

Stereotactic radiosurgery for the treatment of brain metastases. / Müller-Riemenschneider, Falk; Bockelbrink, Angelina; Ernst, Iris et al.
in: Radiotherapy and Oncology, Jahrgang 91, Nr. 1, 04.2009, S. 67-74.

Publikation: Beitrag in FachzeitschriftÜbersichtsarbeitForschungPeer-Review

Müller-Riemenschneider, F, Bockelbrink, A, Ernst, I, Schwarzbach, C, Vauth, C, von der Schulenburg, JMG & Willich, SN 2009, 'Stereotactic radiosurgery for the treatment of brain metastases', Radiotherapy and Oncology, Jg. 91, Nr. 1, S. 67-74. https://doi.org/10.1016/j.radonc.2008.12.001
Müller-Riemenschneider, F., Bockelbrink, A., Ernst, I., Schwarzbach, C., Vauth, C., von der Schulenburg, J. M. G., & Willich, S. N. (2009). Stereotactic radiosurgery for the treatment of brain metastases. Radiotherapy and Oncology, 91(1), 67-74. https://doi.org/10.1016/j.radonc.2008.12.001
Müller-Riemenschneider F, Bockelbrink A, Ernst I, Schwarzbach C, Vauth C, von der Schulenburg JMG et al. Stereotactic radiosurgery for the treatment of brain metastases. Radiotherapy and Oncology. 2009 Apr;91(1):67-74. Epub 2009 Jan 8. doi: 10.1016/j.radonc.2008.12.001
Müller-Riemenschneider, Falk ; Bockelbrink, Angelina ; Ernst, Iris et al. / Stereotactic radiosurgery for the treatment of brain metastases. in: Radiotherapy and Oncology. 2009 ; Jahrgang 91, Nr. 1. S. 67-74.
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abstract = "Background: The objective of this systematic review was to summarise the current evidence concerning radiosurgical treatment (SRS) of newly diagnosed brain metastasis and to compare SRS as a single or additional treatment to treatment alternatives with regard to medical effectiveness and safety. Methods: A structured search of electronic databases was performed to identify relevant publications from 2002 through 2007. Studies targeting patients with brain metastases were included. Standardised quality assessment and data extraction were performed. Results: Of 1496 publications, 16 studies were included. The mean survival in most studies was less than 12 months. There was evidence that SRS plus WBRT was associated with improved local tumour control and neurological functioning compared to either treatment alone. Only in patients with single metastasis, this resulted in improved survival. There was inconclusive evidence when comparing SRS to WBRT, Neurosurgery (NS) or Hypofractionated Radiotherapy (HCSRT). The Quality of life (Qol) was not investigated. Conclusion: SRS plus WBRT was associated with improved local tumour control and neurological functioning compared to either treatment alone. Only in certain patients, this resulted in improved survival. Methodologically rigorous studies are therefore warranted to investigate further treatment options, and in view of the poor prognosis, to investigate Qol and neurological functioning.",
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AU - Müller-Riemenschneider, Falk

AU - Bockelbrink, Angelina

AU - Ernst, Iris

AU - Schwarzbach, Christoph

AU - Vauth, Christoph

AU - von der Schulenburg, J. Matthias Graf

AU - Willich, Stefan N.

N1 - Funding Information: This study was commissioned and in part funded by the German Agency for Health Technology Assessment at the German Institute of Medical Documentation and Information (DAHTA@DIMDI), a subsidiary of the German Federal Ministry of Health. Funding organizations or sponsors had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.

PY - 2009/4

Y1 - 2009/4

N2 - Background: The objective of this systematic review was to summarise the current evidence concerning radiosurgical treatment (SRS) of newly diagnosed brain metastasis and to compare SRS as a single or additional treatment to treatment alternatives with regard to medical effectiveness and safety. Methods: A structured search of electronic databases was performed to identify relevant publications from 2002 through 2007. Studies targeting patients with brain metastases were included. Standardised quality assessment and data extraction were performed. Results: Of 1496 publications, 16 studies were included. The mean survival in most studies was less than 12 months. There was evidence that SRS plus WBRT was associated with improved local tumour control and neurological functioning compared to either treatment alone. Only in patients with single metastasis, this resulted in improved survival. There was inconclusive evidence when comparing SRS to WBRT, Neurosurgery (NS) or Hypofractionated Radiotherapy (HCSRT). The Quality of life (Qol) was not investigated. Conclusion: SRS plus WBRT was associated with improved local tumour control and neurological functioning compared to either treatment alone. Only in certain patients, this resulted in improved survival. Methodologically rigorous studies are therefore warranted to investigate further treatment options, and in view of the poor prognosis, to investigate Qol and neurological functioning.

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