Details
| Titel in Übersetzung | Bestimmung der relativen und absoluten Konfiguration von Thuggacin A–C, hochaktiven Antibiotika aus dem Myxobakterium Sorangium cellulosum |
|---|---|
| Originalsprache | Englisch |
| Seiten (von - bis) | 2308-2311 |
| Seitenumfang | 4 |
| Fachzeitschrift | Angewandte Chemie |
| Jahrgang | 47 |
| Ausgabenummer | 12 |
| Publikationsstatus | Veröffentlicht - 3 März 2008 |
Abstract
Chemistry and biology meet in the structure elucidation of the antibiotics thuggacins A-C. The absolute configuration of all stereogenic centers in the thuggacins was confirmed through a combination of chemical derivatization, NMR analysis, molecular modeling, and bioinformatic analysis of the thuggacin biosynthetic genes. (Chemical Equation Presented).
ASJC Scopus Sachgebiete
- Chemische Verfahrenstechnik (insg.)
- Katalyse
- Chemie (insg.)
- Allgemeine Chemie
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in: Angewandte Chemie , Jahrgang 47, Nr. 12, 03.03.2008, S. 2308-2311.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Stereochemical determination of thuggacins A-C, highly active antibiotics from the myxobacterium Sorangium cellulosum
AU - Bock, Martin
AU - Buntin, Kathrin
AU - Müller, Rolf
AU - Kirschning, Andreas
PY - 2008/3/3
Y1 - 2008/3/3
N2 - Chemistry and biology meet in the structure elucidation of the antibiotics thuggacins A-C. The absolute configuration of all stereogenic centers in the thuggacins was confirmed through a combination of chemical derivatization, NMR analysis, molecular modeling, and bioinformatic analysis of the thuggacin biosynthetic genes. (Chemical Equation Presented).
AB - Chemistry and biology meet in the structure elucidation of the antibiotics thuggacins A-C. The absolute configuration of all stereogenic centers in the thuggacins was confirmed through a combination of chemical derivatization, NMR analysis, molecular modeling, and bioinformatic analysis of the thuggacin biosynthetic genes. (Chemical Equation Presented).
KW - Antibiotics
KW - Gene analysis
KW - Macrolactones
KW - Mosher ester
KW - Structure elucidation
UR - http://www.scopus.com/inward/record.url?scp=41049118134&partnerID=8YFLogxK
U2 - 10.1002/anie.200704897
DO - 10.1002/anie.200704897
M3 - Article
C2 - 18275054
AN - SCOPUS:41049118134
VL - 47
SP - 2308
EP - 2311
JO - Angewandte Chemie
JF - Angewandte Chemie
SN - 1433-7851
IS - 12
ER -