Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 8482-8486 |
| Seitenumfang | 5 |
| Fachzeitschrift | Organic & Biomolecular Chemistry |
| Jahrgang | 19 |
| Ausgabenummer | 39 |
| Frühes Online-Datum | 14 Sept. 2021 |
| Publikationsstatus | Veröffentlicht - 21 Okt. 2021 |
Abstract
The non-canonical fungal α-humulene synthase was investigated through isotopic labelling experiments for its stereochemical course regarding inversion or retention at C-1, the face selectivity at C-11, and the stereoselectivity of the final deprotonation. A new and convenient desymmetrisation strategy was developed to enable a full stereochemical analysis of the catalysed steps to the achiral α-humulene product from stereoselectively labelled farnesyl diphosphate.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Chemie (insg.)
- Physikalische und Theoretische Chemie
- Chemie (insg.)
- Organische Chemie
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in: Organic & Biomolecular Chemistry, Jahrgang 19, Nr. 39, 21.10.2021, S. 8482-8486.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Stereochemical characterisation of the non-canonical alpha-humulene synthase from Acremonium strictum
AU - Xu, Houchao
AU - Schotte, Carsten
AU - Cox, Russell J.
AU - Dickschat, Jeroen S.
N1 - Funding Information: This work was funded by the DFG (DI1536/7-2). We thank Andreas Schneider (Bonn) for skillful technical assistance.
PY - 2021/10/21
Y1 - 2021/10/21
N2 - The non-canonical fungal α-humulene synthase was investigated through isotopic labelling experiments for its stereochemical course regarding inversion or retention at C-1, the face selectivity at C-11, and the stereoselectivity of the final deprotonation. A new and convenient desymmetrisation strategy was developed to enable a full stereochemical analysis of the catalysed steps to the achiral α-humulene product from stereoselectively labelled farnesyl diphosphate.
AB - The non-canonical fungal α-humulene synthase was investigated through isotopic labelling experiments for its stereochemical course regarding inversion or retention at C-1, the face selectivity at C-11, and the stereoselectivity of the final deprotonation. A new and convenient desymmetrisation strategy was developed to enable a full stereochemical analysis of the catalysed steps to the achiral α-humulene product from stereoselectively labelled farnesyl diphosphate.
UR - http://www.scopus.com/inward/record.url?scp=85117222258&partnerID=8YFLogxK
U2 - 10.1039/d1ob01769a
DO - 10.1039/d1ob01769a
M3 - Article
VL - 19
SP - 8482
EP - 8486
JO - Organic & Biomolecular Chemistry
JF - Organic & Biomolecular Chemistry
SN - 1477-0520
IS - 39
ER -