Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 625-634 |
| Seitenumfang | 10 |
| Fachzeitschrift | Archives of toxicology |
| Jahrgang | 83 |
| Ausgabenummer | 6 |
| Publikationsstatus | Veröffentlicht - 9 Dez. 2008 |
Abstract
The statistical evaluation of the in vivo micronucleus assay is focused on multiple contrast tests for comparisons versus the negative control for count data taking the between-animals variability into account. For a possible claim the compound is not genotoxic in the micronucleus assay a proof of safety approach is proposed. For these statistical approaches user-friendly software is free available.
ASJC Scopus Sachgebiete
- Pharmakologie, Toxikologie und Pharmazie (insg.)
- Toxikologie
- Umweltwissenschaften (insg.)
- Gesundheit, Toxikologie und Mutagenese
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in: Archives of toxicology, Jahrgang 83, Nr. 6, 09.12.2008, S. 625-634.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Statistical evaluation of the in vivo micronucleus assay
AU - Hothorn, Ludwig A.
AU - Gerhard, Daniel
N1 - Funding Information: Acknowledgment Parts of this work were supported by EC-JRC, ECVAM, project number CCR.IHCP.C433223.X0.
PY - 2008/12/9
Y1 - 2008/12/9
N2 - The statistical evaluation of the in vivo micronucleus assay is focused on multiple contrast tests for comparisons versus the negative control for count data taking the between-animals variability into account. For a possible claim the compound is not genotoxic in the micronucleus assay a proof of safety approach is proposed. For these statistical approaches user-friendly software is free available.
AB - The statistical evaluation of the in vivo micronucleus assay is focused on multiple contrast tests for comparisons versus the negative control for count data taking the between-animals variability into account. For a possible claim the compound is not genotoxic in the micronucleus assay a proof of safety approach is proposed. For these statistical approaches user-friendly software is free available.
KW - In vivo micronucleus assay
KW - Software
KW - Statistics
UR - http://www.scopus.com/inward/record.url?scp=67651163674&partnerID=8YFLogxK
U2 - 10.1007/s00204-008-0393-8
DO - 10.1007/s00204-008-0393-8
M3 - Article
C2 - 19066853
AN - SCOPUS:67651163674
VL - 83
SP - 625
EP - 634
JO - Archives of toxicology
JF - Archives of toxicology
SN - 0340-5761
IS - 6
ER -