Statistical evaluation of in-vivo bioassays in regulatory toxicology considering males and females

Publikation: Arbeitspapier/Preprint › Preprint

Autoren

  • Ludwig A. Hothorn

Organisationseinheiten

Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
PublikationsstatusElektronisch veröffentlicht (E-Pub) - 10 Nov. 2020

Abstract

The separate evaluation for males and females is the recent standard in in-vivo toxicology for dose or treatment effects using Dunnett tests. The alternative pre-test for sex-by-treatment interaction is problematic. Here a joint test is proposed considering the two sex-specific and the pooled Dunnett-type comparisons. The calculation of either simultaneous confidence intervals or adjusted p-values with the R-package multcomp is demonstrated using a real data example.

Zitieren

Statistical evaluation of in-vivo bioassays in regulatory toxicology considering males and females. / Hothorn, Ludwig A.
2020.

Publikation: Arbeitspapier/Preprint › Preprint

Download
@techreport{c12efb7a46ab4cf8ae82ab626df39f3d,
title = "Statistical evaluation of in-vivo bioassays in regulatory toxicology considering males and females",
abstract = " The separate evaluation for males and females is the recent standard in in-vivo toxicology for dose or treatment effects using Dunnett tests. The alternative pre-test for sex-by-treatment interaction is problematic. Here a joint test is proposed considering the two sex-specific and the pooled Dunnett-type comparisons. The calculation of either simultaneous confidence intervals or adjusted p-values with the R-package multcomp is demonstrated using a real data example. ",
keywords = "stat.AP",
author = "Hothorn, {Ludwig A.}",
year = "2020",
month = nov,
day = "10",
language = "English",
type = "WorkingPaper",

}

Download

TY - UNPB

T1 - Statistical evaluation of in-vivo bioassays in regulatory toxicology considering males and females

AU - Hothorn, Ludwig A.

PY - 2020/11/10

Y1 - 2020/11/10

N2 - The separate evaluation for males and females is the recent standard in in-vivo toxicology for dose or treatment effects using Dunnett tests. The alternative pre-test for sex-by-treatment interaction is problematic. Here a joint test is proposed considering the two sex-specific and the pooled Dunnett-type comparisons. The calculation of either simultaneous confidence intervals or adjusted p-values with the R-package multcomp is demonstrated using a real data example.

AB - The separate evaluation for males and females is the recent standard in in-vivo toxicology for dose or treatment effects using Dunnett tests. The alternative pre-test for sex-by-treatment interaction is problematic. Here a joint test is proposed considering the two sex-specific and the pooled Dunnett-type comparisons. The calculation of either simultaneous confidence intervals or adjusted p-values with the R-package multcomp is demonstrated using a real data example.

KW - stat.AP

M3 - Preprint

BT - Statistical evaluation of in-vivo bioassays in regulatory toxicology considering males and females

ER -