Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1289-1293 |
| Seitenumfang | 5 |
| Fachzeitschrift | Synlett |
| Ausgabenummer | 9 |
| Publikationsstatus | Veröffentlicht - 2000 |
| Extern publiziert | Ja |
Abstract
Two polymeric supports along with two different linkers for attachment to O-4 of carbohydrate-derived glycals were evaluated for the solid phase synthesis of new glycosteroids 9 and 16. From these studies it can be concluded that soluble MPEG-ethers are less well suited polymeric supports for automated synthesis of glycoconjugates. Furthermore, it was found that glycosylation proceeds with much higher selectivity with polymer-bound glycals 3a and 12 compared to the solution variant.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Organische Chemie
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in: Synlett, Nr. 9, 2000, S. 1289-1293.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Soluble versus insoluble polymers as supports for the preparation of new glycosteroids
T2 - A practicability study
AU - Jesberger, Martin
AU - Jaunzems, Janis
AU - Jung, A.
AU - Jas, Gerhard
AU - Schönberger, Andreas
AU - Kirschning, Andreas
PY - 2000
Y1 - 2000
N2 - Two polymeric supports along with two different linkers for attachment to O-4 of carbohydrate-derived glycals were evaluated for the solid phase synthesis of new glycosteroids 9 and 16. From these studies it can be concluded that soluble MPEG-ethers are less well suited polymeric supports for automated synthesis of glycoconjugates. Furthermore, it was found that glycosylation proceeds with much higher selectivity with polymer-bound glycals 3a and 12 compared to the solution variant.
AB - Two polymeric supports along with two different linkers for attachment to O-4 of carbohydrate-derived glycals were evaluated for the solid phase synthesis of new glycosteroids 9 and 16. From these studies it can be concluded that soluble MPEG-ethers are less well suited polymeric supports for automated synthesis of glycoconjugates. Furthermore, it was found that glycosylation proceeds with much higher selectivity with polymer-bound glycals 3a and 12 compared to the solution variant.
KW - Glycosteroid
KW - Linker
KW - Natural product
KW - Solid phase synthesis
UR - http://www.scopus.com/inward/record.url?scp=0033799934&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0033799934
SP - 1289
EP - 1293
JO - Synlett
JF - Synlett
SN - 0936-5214
IS - 9
ER -