Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1358-1368 |
| Seitenumfang | 11 |
| Fachzeitschrift | Cerebral cortex (New York, N.Y. : 1991) |
| Jahrgang | 27 |
| Ausgabenummer | 2 |
| Frühes Online-Datum | 4 Jan. 2016 |
| Publikationsstatus | Veröffentlicht - Feb. 2017 |
| Extern publiziert | Ja |
Abstract
Functional neuroimaging studies have suggested the existence of 2 largely distinct social cognition networks, one for theory of mind (taking others' cognitive perspective) and another for empathy (sharing others' affective states). To address whether these networks can also be dissociated at the level of brain structure, we combined behavioral phenotyping across multiple socio-cognitive tasks with 3-Tesla MRI cortical thickness and structural covariance analysis in 270 healthy adults, recruited across 2 sites. Regional thickness mapping only provided partial support for divergent substrates, highlighting that individual differences in empathy relate to left insular-opercular thickness while no correlation between thickness and mentalizing scores was found. Conversely, structural covariance analysis showed clearly divergent network modulations by socio-cognitive and -affective phenotypes. Specifically, individual differences in theory of mind related to structural integration between temporo-parietal and dorsomedial prefrontal regions while empathy modulated the strength of dorsal anterior insula networks. Findings were robust across both recruitment sites, suggesting generalizability. At the level of structural network embedding, our study provides a double dissociation between empathy and mentalizing. Moreover, our findings suggest that structural substrates of higher-order social cognition are reflected rather in interregional networks than in the the local anatomical markup of specific regions per se.
ASJC Scopus Sachgebiete
- Neurowissenschaften (insg.)
- Kognitive Neurowissenschaft
- Neurowissenschaften (insg.)
- Zelluläre und Molekulare Neurowissenschaften
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in: Cerebral cortex (New York, N.Y. : 1991), Jahrgang 27, Nr. 2, 02.2017, S. 1358-1368.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Socio-Cognitive Phenotypes Differentially Modulate Large-Scale Structural Covariance Networks
AU - Valk, Sofie L.
AU - Bernhardt, Boris C.
AU - Böckler, Anne
AU - Trautwein, Fynn Mathis
AU - Kanske, Philipp
AU - Singer, Tania
PY - 2017/2
Y1 - 2017/2
N2 - Functional neuroimaging studies have suggested the existence of 2 largely distinct social cognition networks, one for theory of mind (taking others' cognitive perspective) and another for empathy (sharing others' affective states). To address whether these networks can also be dissociated at the level of brain structure, we combined behavioral phenotyping across multiple socio-cognitive tasks with 3-Tesla MRI cortical thickness and structural covariance analysis in 270 healthy adults, recruited across 2 sites. Regional thickness mapping only provided partial support for divergent substrates, highlighting that individual differences in empathy relate to left insular-opercular thickness while no correlation between thickness and mentalizing scores was found. Conversely, structural covariance analysis showed clearly divergent network modulations by socio-cognitive and -affective phenotypes. Specifically, individual differences in theory of mind related to structural integration between temporo-parietal and dorsomedial prefrontal regions while empathy modulated the strength of dorsal anterior insula networks. Findings were robust across both recruitment sites, suggesting generalizability. At the level of structural network embedding, our study provides a double dissociation between empathy and mentalizing. Moreover, our findings suggest that structural substrates of higher-order social cognition are reflected rather in interregional networks than in the the local anatomical markup of specific regions per se.
AB - Functional neuroimaging studies have suggested the existence of 2 largely distinct social cognition networks, one for theory of mind (taking others' cognitive perspective) and another for empathy (sharing others' affective states). To address whether these networks can also be dissociated at the level of brain structure, we combined behavioral phenotyping across multiple socio-cognitive tasks with 3-Tesla MRI cortical thickness and structural covariance analysis in 270 healthy adults, recruited across 2 sites. Regional thickness mapping only provided partial support for divergent substrates, highlighting that individual differences in empathy relate to left insular-opercular thickness while no correlation between thickness and mentalizing scores was found. Conversely, structural covariance analysis showed clearly divergent network modulations by socio-cognitive and -affective phenotypes. Specifically, individual differences in theory of mind related to structural integration between temporo-parietal and dorsomedial prefrontal regions while empathy modulated the strength of dorsal anterior insula networks. Findings were robust across both recruitment sites, suggesting generalizability. At the level of structural network embedding, our study provides a double dissociation between empathy and mentalizing. Moreover, our findings suggest that structural substrates of higher-order social cognition are reflected rather in interregional networks than in the the local anatomical markup of specific regions per se.
KW - connectivity
KW - connectome
KW - empathy
KW - social brain
KW - theory of mind
UR - http://www.scopus.com/inward/record.url?scp=85026471870&partnerID=8YFLogxK
U2 - 10.1093/cercor/bhv319
DO - 10.1093/cercor/bhv319
M3 - Article
C2 - 26733538
AN - SCOPUS:85026471870
VL - 27
SP - 1358
EP - 1368
JO - Cerebral cortex (New York, N.Y. : 1991)
JF - Cerebral cortex (New York, N.Y. : 1991)
SN - 1047-3211
IS - 2
ER -