Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 7-18 |
| Seitenumfang | 12 |
| Fachzeitschrift | European Journal of Health Economics |
| Jahrgang | 17 |
| Ausgabenummer | 1 |
| Frühes Online-Datum | 8 Apr. 2016 |
| Publikationsstatus | Veröffentlicht - Apr. 2016 |
Abstract
Objectives: Our goal was to provide data on the economic burden and health-related quality of life (HRQOL) of patients with cystic fibrosis (CF) and their caregivers in Europe. Methods: A cross-sectional study was carried out on adults and children with CF in eight European countries. Patients completed an anonymous questionnaire regarding their socio-demographic characteristics, use of healthcare services and presence of a caregiver. Costs were calculated with a bottom-up approach using unit costs from each participating country, and HRQOL was assessed using EQ-5D. The principal caregiver also answered a questionnaire on their characteristics, HRQOL and burden. Results: A total of 905 patients with CF was included (399 adults and 506 children). The total average annual cost per patient varied from €21,144 in Bulgaria to €53,256 in Germany. Adults had higher direct healthcare costs than children, but children had much higher informal care costs (P < 0.0001). Total costs increased with patients’ level of dependence. In adults, mean utility fell between 0.640 and 0.870, and the visual analogue scale ranged from 46.0 to 69.7. There was no difference in caregiver HRQOL regardless of whether they cared for an adult or a child. However, caregivers who looked after a child had a significantly higher burden (P = 0.0013). Conclusions: Our study highlights the burden of CF in terms of costs and decreased HRQOL for both patients and their caregivers throughout Europe.
ASJC Scopus Sachgebiete
- Volkswirtschaftslehre, Ökonometrie und Finanzen (insg.)
- Volkswirtschaftslehre, Ökonometrie und Finanzen (sonstige)
- Medizin (insg.)
- Health policy
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in: European Journal of Health Economics, Jahrgang 17, Nr. 1, 04.2016, S. 7-18.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Social/economic costs and health-related quality of life in patients with cystic fibrosis in Europe
AU - Chevreul, Karine
AU - Michel, Morgane
AU - Brigham, Karen Berg
AU - López-Bastida, Julio
AU - Linertová, Renata
AU - Oliva-Moreno, Juan
AU - Serrano-Aguilar, Pedro
AU - Posada-de-la-Paz, Manuel
AU - Taruscio, Domenica
AU - Schieppati, Arrigo
AU - Iskrov, Georgi
AU - Péntek, Márta
AU - von der Schulenburg, Johann Matthias Graf
AU - Kanavos, Panos
AU - Persson, Ulf
AU - Fattore, Giovani
N1 - Funding Information: Supported by the Social/Economic Burden and Health-Related Quality of Life in Patients with Rare Diseases in Europe Project, which received funding from the European Union within the framework of the Health Programme [Grant A101205]. The Executive Agency of the European Union is not responsible for any use that may be made of the information contained herein.
PY - 2016/4
Y1 - 2016/4
N2 - Objectives: Our goal was to provide data on the economic burden and health-related quality of life (HRQOL) of patients with cystic fibrosis (CF) and their caregivers in Europe. Methods: A cross-sectional study was carried out on adults and children with CF in eight European countries. Patients completed an anonymous questionnaire regarding their socio-demographic characteristics, use of healthcare services and presence of a caregiver. Costs were calculated with a bottom-up approach using unit costs from each participating country, and HRQOL was assessed using EQ-5D. The principal caregiver also answered a questionnaire on their characteristics, HRQOL and burden. Results: A total of 905 patients with CF was included (399 adults and 506 children). The total average annual cost per patient varied from €21,144 in Bulgaria to €53,256 in Germany. Adults had higher direct healthcare costs than children, but children had much higher informal care costs (P < 0.0001). Total costs increased with patients’ level of dependence. In adults, mean utility fell between 0.640 and 0.870, and the visual analogue scale ranged from 46.0 to 69.7. There was no difference in caregiver HRQOL regardless of whether they cared for an adult or a child. However, caregivers who looked after a child had a significantly higher burden (P = 0.0013). Conclusions: Our study highlights the burden of CF in terms of costs and decreased HRQOL for both patients and their caregivers throughout Europe.
AB - Objectives: Our goal was to provide data on the economic burden and health-related quality of life (HRQOL) of patients with cystic fibrosis (CF) and their caregivers in Europe. Methods: A cross-sectional study was carried out on adults and children with CF in eight European countries. Patients completed an anonymous questionnaire regarding their socio-demographic characteristics, use of healthcare services and presence of a caregiver. Costs were calculated with a bottom-up approach using unit costs from each participating country, and HRQOL was assessed using EQ-5D. The principal caregiver also answered a questionnaire on their characteristics, HRQOL and burden. Results: A total of 905 patients with CF was included (399 adults and 506 children). The total average annual cost per patient varied from €21,144 in Bulgaria to €53,256 in Germany. Adults had higher direct healthcare costs than children, but children had much higher informal care costs (P < 0.0001). Total costs increased with patients’ level of dependence. In adults, mean utility fell between 0.640 and 0.870, and the visual analogue scale ranged from 46.0 to 69.7. There was no difference in caregiver HRQOL regardless of whether they cared for an adult or a child. However, caregivers who looked after a child had a significantly higher burden (P = 0.0013). Conclusions: Our study highlights the burden of CF in terms of costs and decreased HRQOL for both patients and their caregivers throughout Europe.
KW - Costs and cost analysis
KW - Cystic fibrosis
KW - Economic burden
KW - Health-related quality of life
UR - http://www.scopus.com/inward/record.url?scp=84964048197&partnerID=8YFLogxK
U2 - 10.1007/s10198-016-0781-6
DO - 10.1007/s10198-016-0781-6
M3 - Article
C2 - 27059622
AN - SCOPUS:84964048197
VL - 17
SP - 7
EP - 18
JO - European Journal of Health Economics
JF - European Journal of Health Economics
SN - 1618-7598
IS - 1
ER -