TY - JOUR

T1 - Single-Dose SDA-Rich Echium Oil Increases Plasma EPA, DPAn3, and DHA Concentrations

AU - Greupner, Theresa

AU - Koch, Elisabeth

AU - Kutzner, Laura

AU - Hahn, Andreas

AU - Schebb, Nils Helge

AU - Schuchardt, Jan Philipp

N1 - Funding information: This research was funded by DFG, grant number SCHU 2516, SCHE 1801. Acknowledgments: This study was supported by grants from the German Research Foundation (Grant SCHE 1801 and SCHU 2516) to NHS and JPS. We would like to thank the participants who contributed their time to this project and Sarah Reuber, Sebastian Biernacki and Mustafa Bagci for assisting the GC analysis. The publication of this article was funded by the Open Access fund of Leibniz Universität Hannover.

PY - 2019/10

Y1 - 2019/10

N2 - The omega-3 (n3) polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with health benefits. The primary dietary source of EPA and DHA is seafood. Alpha-linoleic acid (ALA) has not been shown to be a good source for EPA and DHA; however, stearidonic acid (SDA)-which is naturally contained in echium oil (EO)-may be a more promising alternative. This study was aimed at investigating the short-term n3 PUFA metabolism after the ingestion of a single dose of EO. Healthy young male subjects (n = 12) ingested a single dose of 26 g of EO after overnight fasting. Plasma fatty acid concentrations and relative amounts were determined at baseline and 2, 4, 6, 8, 24, 48, and 72 h after the ingestion of EO. During the whole examination period, the participants received standardized nutrition. Plasma ALA and SDA concentrations increased rapidly after the single dose of EO. Additionally, EPA and DPAn3 concentrations both increased significantly by 47% after 72 h compared to baseline; DHA concentrations also significantly increased by 21% after 72 h. To conclude, EO increases plasma ALA, SDA, EPA, DPAn3, and DHA concentrations and may be an alternative source for these n3 PUFAs.

AB - The omega-3 (n3) polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with health benefits. The primary dietary source of EPA and DHA is seafood. Alpha-linoleic acid (ALA) has not been shown to be a good source for EPA and DHA; however, stearidonic acid (SDA)-which is naturally contained in echium oil (EO)-may be a more promising alternative. This study was aimed at investigating the short-term n3 PUFA metabolism after the ingestion of a single dose of EO. Healthy young male subjects (n = 12) ingested a single dose of 26 g of EO after overnight fasting. Plasma fatty acid concentrations and relative amounts were determined at baseline and 2, 4, 6, 8, 24, 48, and 72 h after the ingestion of EO. During the whole examination period, the participants received standardized nutrition. Plasma ALA and SDA concentrations increased rapidly after the single dose of EO. Additionally, EPA and DPAn3 concentrations both increased significantly by 47% after 72 h compared to baseline; DHA concentrations also significantly increased by 21% after 72 h. To conclude, EO increases plasma ALA, SDA, EPA, DPAn3, and DHA concentrations and may be an alternative source for these n3 PUFAs.

KW - Administration, Oral

KW - Adult

KW - Docosahexaenoic Acids/blood

KW - Echium

KW - Eicosapentaenoic Acid/blood

KW - Fatty Acids, Omega-3/administration & dosage

KW - Germany

KW - Humans

KW - Lipid Metabolism

KW - Male

KW - Plant Oils/administration & dosage

KW - Time Factors

KW - Young Adult

KW - alpha-Linolenic Acid/blood

KW - Stearidonic acid

KW - Conversion

KW - Polyunsaturated fatty acid metabolism

UR - http://www.scopus.com/inward/record.url?scp=85072911453&partnerID=8YFLogxK

U2 - 10.3390/nu11102346

DO - 10.3390/nu11102346

M3 - Article

C2 - 31581725

VL - 11

JO - NUTRIENTS

JF - NUTRIENTS

SN - 2072-6643

IS - 10

M1 - 2346

ER -