Similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology

Publikation: Arbeitspapier/Preprint › Preprint

Autoren

  • Ludwig A. Hothorn
  • Dimitrios Spiliotopoulos

Organisationseinheiten

Externe Organisationen

  • Xenometrix AG
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Details

OriginalspracheEnglisch
PublikationsstatusElektronisch veröffentlicht (E-Pub) - 25 Sept. 2020

Abstract

To claim similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology is a relevant issue during the assay validation process. Here we demonstrated the use of dose-by-laboratory interaction contrasts, particularly Williams-type by total mean contrasts. With the CRAN packages statint and multcomp in the open-source software R the estimation of adjusted p-values or compatible simultaneous confidence intervals is relatively easy. The interpretation in terms of global or partial equivalence, i.e. similarity, is challenging, because thresholds are not available a-priori. This approach is demonstrated by selected in-vitro Ames MPF assay data.

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Similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology. / Hothorn, Ludwig A.; Spiliotopoulos, Dimitrios.
2020.

Publikation: Arbeitspapier/Preprint › Preprint

Hothorn LA, Spiliotopoulos D. Similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology. 2020 Sep 25. Epub 2020 Sep 25.
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