TY - JOUR

T1 - Role of Goldenberry (Fruits with Husk) Extract in Ameliorating the Architecture and Osmotic Fragility of Red Blood Cells in Obese Rats

AU - Moussa, Sherif A. Abdelmottaleb

AU - Aziz, Samir W.

AU - El-Latif, Noha A. Abd

AU - Bashandy, Samir A. E.

AU - Elbaset, Marawan A.

AU - Afifi, Sherif M.

AU - Esatbeyoglu, Tuba

AU - Toumy, Sayed A. El

AU - Salib, Josline Y.

A2 - Loura, Luis

N1 - The research was funded and supported by the National Research Centre, Cairo, Egypt, under grant number (12060172). The publication of this article was funded by the Open Access Fund of Leibniz Universität Hannover. Open Access funding is enabled and organized by Projekt DEAL. The authors would like to thank Science Shake Inc. for conducting proofreading and English language editing (https://www.science-shake.com/).

PY - 2023/11/27

Y1 - 2023/11/27

N2 - Goldenberry (GB) is a promising fruit that can be a constituent in many possible nourishments. No notifications were obtained regarding the impact of exposure to goldenberry extract in the viewpoint of blood rheological properties as well as erythrocyte osmotic fragility of red blood cells (RBCs) in obese rats. A substantial reduction in plasma triglyceride, total cholesterol, and LDL, with a considerable increment in HDL levels relative to the obese group (p ≤ 0.05), was observed in rats receiving low and high doses of GB, accompanied by restoration of SOD activity and GSH levels. Rheological parameters of rats' blood have been studied over a wide range of shear rates (225-1875 s-1). A significant decrease in blood viscosity in rats who received low and high doses of GB extract was compatible with every shear rate compared to the control group. The shear stress values of the obese rats reduced appreciably (p ≤ 0.05) in all values of shear rate (from 75 to 500 s-1) proportional to the control group, while in the groups that received low and high doses of GB extract, shear stress was restored to the control values. Finally, administration of GB extract significantly decreased yield stress and indices of whole blood aggregation, with an extremely substantial increment in flow rate, in rats given low or high doses of GB compared to obese ones. The result also showed a decrease in both the average raised osmotic fragility and the hemolysis rate in rats after supplementation with low and high doses of GB extract.

AB - Goldenberry (GB) is a promising fruit that can be a constituent in many possible nourishments. No notifications were obtained regarding the impact of exposure to goldenberry extract in the viewpoint of blood rheological properties as well as erythrocyte osmotic fragility of red blood cells (RBCs) in obese rats. A substantial reduction in plasma triglyceride, total cholesterol, and LDL, with a considerable increment in HDL levels relative to the obese group (p ≤ 0.05), was observed in rats receiving low and high doses of GB, accompanied by restoration of SOD activity and GSH levels. Rheological parameters of rats' blood have been studied over a wide range of shear rates (225-1875 s-1). A significant decrease in blood viscosity in rats who received low and high doses of GB extract was compatible with every shear rate compared to the control group. The shear stress values of the obese rats reduced appreciably (p ≤ 0.05) in all values of shear rate (from 75 to 500 s-1) proportional to the control group, while in the groups that received low and high doses of GB extract, shear stress was restored to the control values. Finally, administration of GB extract significantly decreased yield stress and indices of whole blood aggregation, with an extremely substantial increment in flow rate, in rats given low or high doses of GB compared to obese ones. The result also showed a decrease in both the average raised osmotic fragility and the hemolysis rate in rats after supplementation with low and high doses of GB extract.

UR - http://www.scopus.com/inward/record.url?scp=85178850784&partnerID=8YFLogxK

U2 - 10.1155/2023/8794214

DO - 10.1155/2023/8794214

M3 - Article

VL - 2023

SP - 8794214

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 8794214

ER -