Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 318-341 |
| Seitenumfang | 24 |
| Fachzeitschrift | Natural Product Reports |
| Jahrgang | 25 |
| Ausgabenummer | 2 |
| Publikationsstatus | Veröffentlicht - 2008 |
Abstract
A detailed overview is presented of recent total synthesis approaches to four different diterpenoids - the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemistry. Additionally, all four diterpenoids are of major relevance because of their biological (target) or pharmaceutical properties.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Pharmakologie, Toxikologie und Pharmazie (insg.)
- Wirkstoffforschung
- Chemie (insg.)
- Organische Chemie
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in: Natural Product Reports, Jahrgang 25, Nr. 2, 2008, S. 318-341.
Publikation: Beitrag in Fachzeitschrift › Übersichtsarbeit › Forschung › Peer-Review
}
TY - JOUR
T1 - Recent advances in the total synthesis of pharmaceutically relevant diterpenes
AU - Busch, Torsten
AU - Kirschning, Andreas
PY - 2008
Y1 - 2008
N2 - A detailed overview is presented of recent total synthesis approaches to four different diterpenoids - the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemistry. Additionally, all four diterpenoids are of major relevance because of their biological (target) or pharmaceutical properties.
AB - A detailed overview is presented of recent total synthesis approaches to four different diterpenoids - the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemistry. Additionally, all four diterpenoids are of major relevance because of their biological (target) or pharmaceutical properties.
UR - http://www.scopus.com/inward/record.url?scp=41849127508&partnerID=8YFLogxK
U2 - 10.1039/b705652b
DO - 10.1039/b705652b
M3 - Review article
C2 - 18389140
AN - SCOPUS:41849127508
VL - 25
SP - 318
EP - 341
JO - Natural Product Reports
JF - Natural Product Reports
SN - 0265-0568
IS - 2
ER -