TY - JOUR

T1 - Recent advances in melt electro writing for tissue engineering for 3D printing of microporous scaffolds for tissue engineering

AU - Loewner, Sebastian

AU - Heene, Sebastian

AU - Baroth, Timo

AU - Heymann, Henrik

AU - Cholewa, Fabian

AU - Blume, Holger

AU - Blume, Cornelia

N1 - Funding Information: This work has been carried out within the framework of the SMART BIOTECS alliance between the Technische Universitaet Braunschweig and the Leibniz Universitaet Hannover. This initiative is supported by the Ministry of Economy and Culture (MWK) of Lower Saxony, Germany. The publication of this article was funded by the Open Access Fund of Leibniz Universitaet Hannover.

PY - 2022/8/17

Y1 - 2022/8/17

N2 - Melt electro writing (MEW) is a high-resolution 3D printing technique that combines elements of electro-hydrodynamic fiber attraction and melts extrusion. The ability to precisely deposit micro- to nanometer strands of biocompatible polymers in a layer-by-layer fashion makes MEW a promising scaffold fabrication method for all kinds of tissue engineering applications. This review describes possibilities to optimize multi-parametric MEW processes for precise fiber deposition over multiple layers and prevent printing defects. Printing protocols for nonlinear scaffolds structures, concrete MEW scaffold pore geometries and printable biocompatible materials for MEW are introduced. The review discusses approaches to combining MEW with other fabrication techniques with the purpose to generate advanced scaffolds structures. The outlined MEW printer modifications enable customizable collector shapes or sacrificial materials for non-planar fiber deposition and nozzle adjustments allow redesigned fiber properties for specific applications. Altogether, MEW opens a new chapter of scaffold design by 3D printing.

AB - Melt electro writing (MEW) is a high-resolution 3D printing technique that combines elements of electro-hydrodynamic fiber attraction and melts extrusion. The ability to precisely deposit micro- to nanometer strands of biocompatible polymers in a layer-by-layer fashion makes MEW a promising scaffold fabrication method for all kinds of tissue engineering applications. This review describes possibilities to optimize multi-parametric MEW processes for precise fiber deposition over multiple layers and prevent printing defects. Printing protocols for nonlinear scaffolds structures, concrete MEW scaffold pore geometries and printable biocompatible materials for MEW are introduced. The review discusses approaches to combining MEW with other fabrication techniques with the purpose to generate advanced scaffolds structures. The outlined MEW printer modifications enable customizable collector shapes or sacrificial materials for non-planar fiber deposition and nozzle adjustments allow redesigned fiber properties for specific applications. Altogether, MEW opens a new chapter of scaffold design by 3D printing.

KW - 3D printing

KW - electrospinning

KW - melt electro writing

KW - scaffolds

KW - tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=85137148318&partnerID=8YFLogxK

U2 - 10.3389/fbioe.2022.896719

DO - 10.3389/fbioe.2022.896719

M3 - Review article

C2 - 36061443

VL - 10

JO - Frontiers in Bioengineering and Biotechnology

JF - Frontiers in Bioengineering and Biotechnology

SN - 2296-4185

M1 - 896719

ER -