Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1624-1633 |
| Seitenumfang | 10 |
| Fachzeitschrift | Organic and Biomolecular Chemistry |
| Jahrgang | 17 |
| Ausgabenummer | 7 |
| Publikationsstatus | Veröffentlicht - 24 Okt. 2018 |
Abstract
Classical steroids are long-known privileged leads in drug discovery. Their rearranged counterparts, though, have so far received less attention, although recent isolation and biological testing programmes have revealed a plethora of molecular entities that are both structurally intriguing, as well as biologically relevant. This review will highlight those natural products, and focus on ergostane-derived seco- and abeo-steroids. Their isolation, structure elucidation, and biological properties are reported. A special emphasis of this review lies in their respective (and typically proposed) biosyntheses, to help guide future bio-inspired synthetic attempts.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Chemie (insg.)
- Physikalische und Theoretische Chemie
- Chemie (insg.)
- Organische Chemie
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in: Organic and Biomolecular Chemistry, Jahrgang 17, Nr. 7, 24.10.2018, S. 1624-1633.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung
}
TY - JOUR
T1 - Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects
AU - Duecker, Fenja L.
AU - Reuss, Franziska
AU - Heretsch, Philipp
PY - 2018/10/24
Y1 - 2018/10/24
N2 - Classical steroids are long-known privileged leads in drug discovery. Their rearranged counterparts, though, have so far received less attention, although recent isolation and biological testing programmes have revealed a plethora of molecular entities that are both structurally intriguing, as well as biologically relevant. This review will highlight those natural products, and focus on ergostane-derived seco- and abeo-steroids. Their isolation, structure elucidation, and biological properties are reported. A special emphasis of this review lies in their respective (and typically proposed) biosyntheses, to help guide future bio-inspired synthetic attempts.
AB - Classical steroids are long-known privileged leads in drug discovery. Their rearranged counterparts, though, have so far received less attention, although recent isolation and biological testing programmes have revealed a plethora of molecular entities that are both structurally intriguing, as well as biologically relevant. This review will highlight those natural products, and focus on ergostane-derived seco- and abeo-steroids. Their isolation, structure elucidation, and biological properties are reported. A special emphasis of this review lies in their respective (and typically proposed) biosyntheses, to help guide future bio-inspired synthetic attempts.
UR - http://www.scopus.com/inward/record.url?scp=85060018959&partnerID=8YFLogxK
U2 - 10.1039/c8ob02325e
DO - 10.1039/c8ob02325e
M3 - Article
VL - 17
SP - 1624
EP - 1633
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
SN - 1477-0520
IS - 7
ER -