Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 369-371 |
| Seitenumfang | 3 |
| Fachzeitschrift | CHEMBIOCHEM |
| Jahrgang | 5 |
| Ausgabenummer | 3 |
| Publikationsstatus | Veröffentlicht - 5 März 2004 |
Abstract
Adding more sugar: Overexpression of the landomycin glycosyltransferase gene lanGT4 in Streptomyces fradiae Tü2717 resulted in the conversion of the urdamycin trisaccharide into an unnatural tetrasaccharide by transfer of an L-rhodinose unit. We propose that LanGT4 is able to act iteratively on growing saccharide chains.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Molekularmedizin
- Biochemie, Genetik und Molekularbiologie (insg.)
- Molekularbiologie
- Chemie (insg.)
- Organische Chemie
Zitieren
- Standard
- Harvard
- Apa
- Vancouver
- BibTex
- RIS
in: CHEMBIOCHEM, Jahrgang 5, Nr. 3, 05.03.2004, S. 369-371.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Rational saccharide extension by using the natural product glycosyltransferase LanGT4
AU - Hoffmeister, Dirk
AU - Weber, Monika
AU - Dräger, Gerald
AU - Ichinose, Koji
AU - Dürr, Clemens
AU - Bechthold, Andreas
N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/3/5
Y1 - 2004/3/5
N2 - Adding more sugar: Overexpression of the landomycin glycosyltransferase gene lanGT4 in Streptomyces fradiae Tü2717 resulted in the conversion of the urdamycin trisaccharide into an unnatural tetrasaccharide by transfer of an L-rhodinose unit. We propose that LanGT4 is able to act iteratively on growing saccharide chains.
AB - Adding more sugar: Overexpression of the landomycin glycosyltransferase gene lanGT4 in Streptomyces fradiae Tü2717 resulted in the conversion of the urdamycin trisaccharide into an unnatural tetrasaccharide by transfer of an L-rhodinose unit. We propose that LanGT4 is able to act iteratively on growing saccharide chains.
KW - Biosynthesis
KW - Drug design
KW - Enzymes
KW - Glycosyltransferase
KW - Urdamycin
UR - http://www.scopus.com/inward/record.url?scp=4544369703&partnerID=8YFLogxK
U2 - 10.1002/cbic.200300793
DO - 10.1002/cbic.200300793
M3 - Article
C2 - 14997529
AN - SCOPUS:4544369703
VL - 5
SP - 369
EP - 371
JO - CHEMBIOCHEM
JF - CHEMBIOCHEM
SN - 1439-4227
IS - 3
ER -