Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 622-626 |
| Seitenumfang | 5 |
| Fachzeitschrift | Advanced Synthesis and Catalysis |
| Jahrgang | 344 |
| Ausgabenummer | 6-7 |
| Publikationsstatus | Veröffentlicht - 20 Aug. 2002 |
| Extern publiziert | Ja |
Abstract
A new strategy for the synthesis of a well-defined glycolipid library is presented. A highly selective cross metathesis reaction is used to diversify the lipid moiety of anomerically pure α- or β-glycosides, and subsequent functionalization of the double bond allows further expansion of the diversity. These glycolipids are being investigated for their effect on the immune system, especially the CD1-mediated T-cell activation.
ASJC Scopus Sachgebiete
- Chemische Verfahrenstechnik (insg.)
- Katalyse
- Chemie (insg.)
- Organische Chemie
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in: Advanced Synthesis and Catalysis, Jahrgang 344, Nr. 6-7, 20.08.2002, S. 622-626.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Rapid preparation of glycolipid libraries by cross metathesis
AU - Plettenburg, Oliver
AU - Mui, Cosina
AU - Bodmer-Narkevitch, Vera
AU - Wong, Chi Huey
PY - 2002/8/20
Y1 - 2002/8/20
N2 - A new strategy for the synthesis of a well-defined glycolipid library is presented. A highly selective cross metathesis reaction is used to diversify the lipid moiety of anomerically pure α- or β-glycosides, and subsequent functionalization of the double bond allows further expansion of the diversity. These glycolipids are being investigated for their effect on the immune system, especially the CD1-mediated T-cell activation.
AB - A new strategy for the synthesis of a well-defined glycolipid library is presented. A highly selective cross metathesis reaction is used to diversify the lipid moiety of anomerically pure α- or β-glycosides, and subsequent functionalization of the double bond allows further expansion of the diversity. These glycolipids are being investigated for their effect on the immune system, especially the CD1-mediated T-cell activation.
KW - Cross metathesis
KW - Glycolipid library
KW - Parallel synthesis
UR - http://www.scopus.com/inward/record.url?scp=0141469359&partnerID=8YFLogxK
U2 - 10.1002/1615-4169(200208)344:6/7<622::AID-ADSC622>3.0.CO;2-W
DO - 10.1002/1615-4169(200208)344:6/7<622::AID-ADSC622>3.0.CO;2-W
M3 - Article
AN - SCOPUS:0141469359
VL - 344
SP - 622
EP - 626
JO - Advanced Synthesis and Catalysis
JF - Advanced Synthesis and Catalysis
SN - 1615-4150
IS - 6-7
ER -