TY - JOUR

T1 - Pulsed photothermal radiometry as a method for investigating blood vessel-like structures

AU - Schmitz, C. H.

AU - Oberheide, U.

AU - Lohmann, S.

AU - Lubatschowski, H.

AU - Ertmer, W.

PY - 2001/4/1

Y1 - 2001/4/1

N2 - Pulsed photothermal radiometry (PPTR) is known to be suitable for in vivo investigations of tissue optical properties. As a noncontact, nondestructive method it is a very attractive candidate for on-line dosimetry of laser treatments that rely on thermal laser-tissue interaction. In this article, we extend the one-dimensional (1D) analytical formalism that has widely been used to describe PPTR signals to a two-dimensional treatment of a simplified model of a blood vessel. This approach leads to quantitative description of a PPTR signal that, unlike in an 1D treatment, not only shows changes in time, but also varies in space. Using this approach, we are able to gain instructive understanding on how target characteristics of a blood vessel-like structure influence such a spatiotemporal PPTR signal. Likewise, the ability of extracting target features from those measurements is evaluated. Subsequently, we present experimental realization of the idealized model of a blood vessel as used in our theory. Comparison of actual PPTR measurements with theoretical predictions allow vessel localization laterally and in depth. Using our setup, we furthermore demonstrate the influence of flow inside the vessel on the measured signal.

AB - Pulsed photothermal radiometry (PPTR) is known to be suitable for in vivo investigations of tissue optical properties. As a noncontact, nondestructive method it is a very attractive candidate for on-line dosimetry of laser treatments that rely on thermal laser-tissue interaction. In this article, we extend the one-dimensional (1D) analytical formalism that has widely been used to describe PPTR signals to a two-dimensional treatment of a simplified model of a blood vessel. This approach leads to quantitative description of a PPTR signal that, unlike in an 1D treatment, not only shows changes in time, but also varies in space. Using this approach, we are able to gain instructive understanding on how target characteristics of a blood vessel-like structure influence such a spatiotemporal PPTR signal. Likewise, the ability of extracting target features from those measurements is evaluated. Subsequently, we present experimental realization of the idealized model of a blood vessel as used in our theory. Comparison of actual PPTR measurements with theoretical predictions allow vessel localization laterally and in depth. Using our setup, we furthermore demonstrate the influence of flow inside the vessel on the measured signal.

KW - Blood flow

KW - Blood vessels

KW - On-line-dosimetry

KW - Pulsed photothermal radiometry

KW - Thermal imaging

KW - Tissue optics

UR - http://www.scopus.com/inward/record.url?scp=0035297595&partnerID=8YFLogxK

U2 - 10.1117/1.1344193

DO - 10.1117/1.1344193

M3 - Article

C2 - 11375732

AN - SCOPUS:0035297595

VL - 6

SP - 214

EP - 223

JO - Journal of biomedical optics

JF - Journal of biomedical optics

SN - 1083-3668

IS - 2

ER -