Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 3585-3589 |
| Seitenumfang | 5 |
| Fachzeitschrift | FEBS Letters |
| Jahrgang | 582 |
| Ausgabenummer | 25-26 |
| Publikationsstatus | Veröffentlicht - 29 Okt. 2008 |
| Extern publiziert | Ja |
Abstract
The phage shock protein A (PspA) of Escherichia coli stabilizes the cytoplasmic membrane under stress conditions. Here we demonstrate that PspA can form hollow spherical or prolate spheroidal particles of about 30-40 nm diameter with a scaffold-like arrangement of protein subunits at the surface. The 'PspA-scaffold' is the basic structure that is common to all particles. The PspA-scaffold may be of fundamental importance, as it could allow PspA to stabilize the integrity of membranes through numerous contact points over a large surface area.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biophysik
- Biochemie, Genetik und Molekularbiologie (insg.)
- Strukturelle Biologie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Molekularbiologie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Genetik
- Biochemie, Genetik und Molekularbiologie (insg.)
- Zellbiologie
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in: FEBS Letters, Jahrgang 582, Nr. 25-26, 29.10.2008, S. 3585-3589.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - PspA can form large scaffolds in Escherichia coli
AU - Standar, Kerstin
AU - Mehner, Denise
AU - Osadnik, Hendrik
AU - Berthelmann, Felix
AU - Hause, Gerd
AU - Lünsdorf, Heinrich
AU - Brüser, Thomas
N1 - Funding Information: We are grateful to Jan R. Andreesen and Gary Sawers for discussions and support. This work was supported by the Deutsche Forschungsgemeinschaft with Grant BR2285/2-2 to T.B. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008/10/29
Y1 - 2008/10/29
N2 - The phage shock protein A (PspA) of Escherichia coli stabilizes the cytoplasmic membrane under stress conditions. Here we demonstrate that PspA can form hollow spherical or prolate spheroidal particles of about 30-40 nm diameter with a scaffold-like arrangement of protein subunits at the surface. The 'PspA-scaffold' is the basic structure that is common to all particles. The PspA-scaffold may be of fundamental importance, as it could allow PspA to stabilize the integrity of membranes through numerous contact points over a large surface area.
AB - The phage shock protein A (PspA) of Escherichia coli stabilizes the cytoplasmic membrane under stress conditions. Here we demonstrate that PspA can form hollow spherical or prolate spheroidal particles of about 30-40 nm diameter with a scaffold-like arrangement of protein subunits at the surface. The 'PspA-scaffold' is the basic structure that is common to all particles. The PspA-scaffold may be of fundamental importance, as it could allow PspA to stabilize the integrity of membranes through numerous contact points over a large surface area.
KW - Membrane stabilization
KW - Membrane stress
KW - Phage shock protein
UR - http://www.scopus.com/inward/record.url?scp=53949112044&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2008.09.002
DO - 10.1016/j.febslet.2008.09.002
M3 - Article
C2 - 18789328
AN - SCOPUS:53949112044
VL - 582
SP - 3585
EP - 3589
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 25-26
ER -