TY - JOUR

T1 - Processing and coating of open-pored absorbable magnesium-based bone implants

AU - Julmi, Stefan

AU - Krüger, Ann Kathrin

AU - Waselau, Anja Christina

AU - Meyer-Lindenberg, Andrea

AU - Wriggers, Peter

AU - Klose, Christian

AU - Maier, Hans Jürgen

N1 - Funding Information: This research was supported by the German Research Foundation (DFG) within the project “Interfacial effects and ingrowing behaviour of magnesium-based foams as bioresorbable bone substitute material” (grant No. MA 1175/52-1, ME 1941/3-1 and WR 19/56-1; 271761343). The Xradia 520 Versa (grant No. MA1175/67-1; 316923185) that has been used in this study, was sponsored by the DFG.

PY - 2019/5

Y1 - 2019/5

N2 - Large bone defects or fractures must be treated with an implant or transplant. Resorbable implants are attractive as these require only one surgery, whereas bone autografts, which can be cut off from the same person's hip, require more than one procedure. Moreover, porous structures promote the ingrowth of the patient's bone. Thus, the objective of the present study was to develop open-pored biodegradable implant structures with different pore sizes that provide for both adequate degradation behaviour and mechanical properties that match with those of bone. The magnesium alloys LAE442 and La2 were employed in this study, as these materials are known to feature good biocompatibility and mechanical properties close to bone. It was possible to cast magnesium sponges with different pore sizes using the alloy LAE442. However, with the Mg–La2 alloy, only sponges with a minimum pore size of 0.5 mm could be produced. Overall, the sponges cast with the LAE442 alloy showed higher strength, even though the strengths of the dense parts were similar in both alloys tested. In terms of castability and mechanical behaviour, the LAE442 alloy turned out to be more favourable. In order to adapt the implant degradation behaviour to the bone ingrowth behaviour, coating of the magnesium sponges with calcium phosphate and polylactic acid was also investigated. Additionally, the different coatings were tested on their adhesive forces and influences to the in-vitro degradation behaviour.

AB - Large bone defects or fractures must be treated with an implant or transplant. Resorbable implants are attractive as these require only one surgery, whereas bone autografts, which can be cut off from the same person's hip, require more than one procedure. Moreover, porous structures promote the ingrowth of the patient's bone. Thus, the objective of the present study was to develop open-pored biodegradable implant structures with different pore sizes that provide for both adequate degradation behaviour and mechanical properties that match with those of bone. The magnesium alloys LAE442 and La2 were employed in this study, as these materials are known to feature good biocompatibility and mechanical properties close to bone. It was possible to cast magnesium sponges with different pore sizes using the alloy LAE442. However, with the Mg–La2 alloy, only sponges with a minimum pore size of 0.5 mm could be produced. Overall, the sponges cast with the LAE442 alloy showed higher strength, even though the strengths of the dense parts were similar in both alloys tested. In terms of castability and mechanical behaviour, the LAE442 alloy turned out to be more favourable. In order to adapt the implant degradation behaviour to the bone ingrowth behaviour, coating of the magnesium sponges with calcium phosphate and polylactic acid was also investigated. Additionally, the different coatings were tested on their adhesive forces and influences to the in-vitro degradation behaviour.

KW - Biocompatible magnesium alloys

KW - Coating

KW - Investment casting

KW - Magnesium sponges

KW - Resorbable implants

KW - Magnesium/chemistry

KW - Biocompatible Materials/chemistry

KW - Bone and Bones/metabolism

KW - Humans

KW - Calcium Phosphates/chemistry

KW - Absorbable Implants

KW - Alloys/chemistry

KW - Bone Transplantation/methods

KW - Materials Testing/methods

KW - Porosity

UR - http://www.scopus.com/inward/record.url?scp=85060230928&partnerID=8YFLogxK

U2 - 10.1016/j.msec.2018.12.125

DO - 10.1016/j.msec.2018.12.125

M3 - Article

C2 - 30812991

AN - SCOPUS:85060230928

VL - 98

SP - 1073

EP - 1086

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

SN - 0928-4931

ER -