Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 9511–9515 |
| Seitenumfang | 5 |
| Fachzeitschrift | Analytical chemistry |
| Jahrgang | 92 |
| Ausgabenummer | 14 |
| Frühes Online-Datum | 19 Juni 2020 |
| Publikationsstatus | Veröffentlicht - 21 Juli 2020 |
| Extern publiziert | Ja |
Abstract
The determination of solubility limits of compounds in water is unprecise and relies on certain prerequisites such as UV-vis absorption activity. In this study, we designed an experimental approach based on potentiometric titrations to determine solubility limits of various organic compounds by exploiting their pH-active carboxylic acid groups. By applying the law of mass action, utilizing a double-dosing method ensuring a constant compound concentration, it is possible to determine the intrinsic solubility limits, which are independent of the pH value. The derived equations enable the precise and fast determination of intrinsic solubility limits of organic compounds in aqueous solutions within 2-4 h. Moreover, it is shown how the pKa value can be determined based on titrations carried out at two different compound concentrations.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Analytische Chemie
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in: Analytical chemistry, Jahrgang 92, Nr. 14, 21.07.2020, S. 9511–9515.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Potentiometric Titration Method for the Determination of Solubility Limits and pKa Values of Weak Organic Acids in Water
AU - Wiedenbeck, Eduard
AU - Gebauer, Denis
AU - Cölfen, Helmut
N1 - Funding information: E.W. and H.C. thank Deutsche Forschungsgemeinschaft (DFG) for financial support of this work (CO 194/21-1).
PY - 2020/7/21
Y1 - 2020/7/21
N2 - The determination of solubility limits of compounds in water is unprecise and relies on certain prerequisites such as UV-vis absorption activity. In this study, we designed an experimental approach based on potentiometric titrations to determine solubility limits of various organic compounds by exploiting their pH-active carboxylic acid groups. By applying the law of mass action, utilizing a double-dosing method ensuring a constant compound concentration, it is possible to determine the intrinsic solubility limits, which are independent of the pH value. The derived equations enable the precise and fast determination of intrinsic solubility limits of organic compounds in aqueous solutions within 2-4 h. Moreover, it is shown how the pKa value can be determined based on titrations carried out at two different compound concentrations.
AB - The determination of solubility limits of compounds in water is unprecise and relies on certain prerequisites such as UV-vis absorption activity. In this study, we designed an experimental approach based on potentiometric titrations to determine solubility limits of various organic compounds by exploiting their pH-active carboxylic acid groups. By applying the law of mass action, utilizing a double-dosing method ensuring a constant compound concentration, it is possible to determine the intrinsic solubility limits, which are independent of the pH value. The derived equations enable the precise and fast determination of intrinsic solubility limits of organic compounds in aqueous solutions within 2-4 h. Moreover, it is shown how the pKa value can be determined based on titrations carried out at two different compound concentrations.
UR - http://www.scopus.com/inward/record.url?scp=85094213919&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.0c00247
DO - 10.1021/acs.analchem.0c00247
M3 - Article
VL - 92
SP - 9511
EP - 9515
JO - Analytical chemistry
JF - Analytical chemistry
SN - 0003-2700
IS - 14
ER -