Details
| Originalsprache | Englisch |
|---|---|
| Titel des Sammelwerks | Mesenchymal Stem Cells |
| Untertitel | Basics and Clinical Application I |
| Herausgeber/-innen | Birgit Weyand, Ralf Hass, Roland Jacobs, Massimo Dominici, Cornelia Kasper |
| Seiten | 73-88 |
| Seitenumfang | 16 |
| Publikationsstatus | Veröffentlicht - 2013 |
Publikationsreihe
| Name | Advances in Biochemical Engineering/Biotechnology |
|---|---|
| Band | 129 |
| ISSN (Print) | 0724-6145 |
Abstract
The introduction of mesenchymal stem cells (MSC) into the field of tissue engineering for bone and cartilage repair is a promising development, since these cells can be expanded ex vivo to clinically relevant numbers and, after expansion, retain their ability to differentiate into different cell lineages. Mesenchymal stem cells isolated from various tissues have been intensively studied and characterized by many research groups. To obtain functionally active differentiated tissue, tissue engineered constructs are cultivated in vitro statically or dynamically in bioreactors under controlled conditions. These conditions include special cell culture media, addition of signalling molecules, various physical and chemical factors and the application of different mechanical stimuli. Oxygen concentration in the culture environment is also a significant factor which influences MSC proliferation, stemness and differentiation capacity. Knowledge of the different aspects which affect MSC differentiation in vivo and in vitro will help researchers to achieve directed cell fate without the addition of differentiation agents in concentrations above the physiological range.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biotechnologie
- Chemische Verfahrenstechnik (insg.)
- Bioengineering
- Immunologie und Mikrobiologie (insg.)
- Angewandte Mikrobiologie und Biotechnologie
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Mesenchymal Stem Cells: Basics and Clinical Application I. Hrsg. / Birgit Weyand; Ralf Hass; Roland Jacobs; Massimo Dominici; Cornelia Kasper. 2013. S. 73-88 (Advances in Biochemical Engineering/Biotechnology; Band 129).
Publikation: Beitrag in Buch/Bericht/Sammelwerk/Konferenzband › Beitrag in Buch/Sammelwerk › Forschung › Peer-Review
}
TY - CHAP
T1 - Potential for osteogenic and chondrogenic differentiation of MSC
AU - Lavrentieva, Antonina
AU - Hatlapatka, Tim
AU - Neumann, Anne
AU - Weyand, Birgit
AU - Kasper, Cornelia
N1 - Copyright: Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - The introduction of mesenchymal stem cells (MSC) into the field of tissue engineering for bone and cartilage repair is a promising development, since these cells can be expanded ex vivo to clinically relevant numbers and, after expansion, retain their ability to differentiate into different cell lineages. Mesenchymal stem cells isolated from various tissues have been intensively studied and characterized by many research groups. To obtain functionally active differentiated tissue, tissue engineered constructs are cultivated in vitro statically or dynamically in bioreactors under controlled conditions. These conditions include special cell culture media, addition of signalling molecules, various physical and chemical factors and the application of different mechanical stimuli. Oxygen concentration in the culture environment is also a significant factor which influences MSC proliferation, stemness and differentiation capacity. Knowledge of the different aspects which affect MSC differentiation in vivo and in vitro will help researchers to achieve directed cell fate without the addition of differentiation agents in concentrations above the physiological range.
AB - The introduction of mesenchymal stem cells (MSC) into the field of tissue engineering for bone and cartilage repair is a promising development, since these cells can be expanded ex vivo to clinically relevant numbers and, after expansion, retain their ability to differentiate into different cell lineages. Mesenchymal stem cells isolated from various tissues have been intensively studied and characterized by many research groups. To obtain functionally active differentiated tissue, tissue engineered constructs are cultivated in vitro statically or dynamically in bioreactors under controlled conditions. These conditions include special cell culture media, addition of signalling molecules, various physical and chemical factors and the application of different mechanical stimuli. Oxygen concentration in the culture environment is also a significant factor which influences MSC proliferation, stemness and differentiation capacity. Knowledge of the different aspects which affect MSC differentiation in vivo and in vitro will help researchers to achieve directed cell fate without the addition of differentiation agents in concentrations above the physiological range.
KW - Chondrogenesis
KW - Hypoxia
KW - Mechanical stimulation
KW - Mesenchymal stem cells
KW - Mesenchymal stromal cells
KW - Osteogenesis
UR - http://www.scopus.com/inward/record.url?scp=84883023487&partnerID=8YFLogxK
U2 - 10.1007/10_2012_133
DO - 10.1007/10_2012_133
M3 - Contribution to book/anthology
C2 - 22457052
AN - SCOPUS:84883023487
SN - 9783642356704
T3 - Advances in Biochemical Engineering/Biotechnology
SP - 73
EP - 88
BT - Mesenchymal Stem Cells
A2 - Weyand, Birgit
A2 - Hass, Ralf
A2 - Jacobs, Roland
A2 - Dominici, Massimo
A2 - Kasper, Cornelia
ER -