Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 112058 |
| Seitenumfang | 13 |
| Fachzeitschrift | Journal of biomechanics |
| Jahrgang | 166 |
| Frühes Online-Datum | 24 März 2024 |
| Publikationsstatus | Veröffentlicht - März 2024 |
Abstract
This work presents the application of a chemo-mechano-biological constitutive model of soft tissues for describing tissue inflammatory response to damage in collagen constituents. The material model is implemented into a nonlinear finite element formulation to follow up a coronary standard balloon angioplasty for one year. Numerical results, compared with available in vivo clinical data, show that the model reproduces the temporal dynamics of vessel remodeling associated with subintimal damage. Such dynamics are bimodular, being characterized by an early tissue resorption and lumen enlargement, followed by late tissue growth and vessel constriction. Applicability of the modeling framework in retrospective studies is demonstrated, and future extension towards prospective applications is discussed.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biophysik
- Ingenieurwesen (insg.)
- Biomedizintechnik
- Medizin (insg.)
- Orthopädie und Sportmedizin
- Medizin (insg.)
- Rehabilitation
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in: Journal of biomechanics, Jahrgang 166, 112058, 03.2024.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Post-angioplasty remodeling of coronary arteries investigated via a chemo-mechano-biological in silico model
AU - Gierig, Meike
AU - Gaziano, Pierfrancesco
AU - Wriggers, Peter
AU - Marino, Michele
N1 - Funding Information: MM and PG gratefully acknowledge funding from Regione Lazio (POR FESR LAZIO 2014; Progetti di Gruppi di Ricerca 2020; project: BIOPMEAT, n. A0375-2020-36756) and support from the Italian National Group for Mathematical Physics GNFM-INdAM. PW gratefully acknowledges the support by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - SFB/TRR-298-SIIRI - Project-ID 426335750.
PY - 2024/3
Y1 - 2024/3
N2 - This work presents the application of a chemo-mechano-biological constitutive model of soft tissues for describing tissue inflammatory response to damage in collagen constituents. The material model is implemented into a nonlinear finite element formulation to follow up a coronary standard balloon angioplasty for one year. Numerical results, compared with available in vivo clinical data, show that the model reproduces the temporal dynamics of vessel remodeling associated with subintimal damage. Such dynamics are bimodular, being characterized by an early tissue resorption and lumen enlargement, followed by late tissue growth and vessel constriction. Applicability of the modeling framework in retrospective studies is demonstrated, and future extension towards prospective applications is discussed.
AB - This work presents the application of a chemo-mechano-biological constitutive model of soft tissues for describing tissue inflammatory response to damage in collagen constituents. The material model is implemented into a nonlinear finite element formulation to follow up a coronary standard balloon angioplasty for one year. Numerical results, compared with available in vivo clinical data, show that the model reproduces the temporal dynamics of vessel remodeling associated with subintimal damage. Such dynamics are bimodular, being characterized by an early tissue resorption and lumen enlargement, followed by late tissue growth and vessel constriction. Applicability of the modeling framework in retrospective studies is demonstrated, and future extension towards prospective applications is discussed.
KW - Balloon angioplasty
KW - Chemo-mechano-biological model
KW - In silico medicine
KW - Tissue inflammatory response
KW - Vessel remodeling
UR - http://www.scopus.com/inward/record.url?scp=85188678647&partnerID=8YFLogxK
U2 - 10.1016/j.jbiomech.2024.112058
DO - 10.1016/j.jbiomech.2024.112058
M3 - Article
AN - SCOPUS:85188678647
VL - 166
JO - Journal of biomechanics
JF - Journal of biomechanics
SN - 0021-9290
M1 - 112058
ER -