Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 143-152 |
| Seitenumfang | 10 |
| Fachzeitschrift | Materials Science and Engineering C |
| Jahrgang | 68 |
| Frühes Online-Datum | 26 Mai 2016 |
| Publikationsstatus | Veröffentlicht - 1 Nov. 2016 |
Abstract
Porous and cytocompatible silicon carbide (SiC) ceramics derived from wood precursors and coated with bioactive hydroxyapatite (HA) and HA-zirconium dioxide (HA/ZrO2) composite are materials with promising application in engineering of bone implants due to their excellent mechanical and structural properties. Biomorphic SiC ceramics have been synthesized from wood (Hornbeam, Sapele, Tilia and Pear) using a forced impregnation method. The SiC ceramics have been coated with bioactive HA and HA/ZrO2 using effective gas detonation deposition approach (GDD). The surface morphology and cytotoxicity of SiC ceramics as well as phase composition and crystallinity of deposited coatings were analyzed. It has been shown that the porosity and pore size of SiC ceramics depend on initial wood source. The XRD and FTIR studies revealed the preservation of crystal structure and phase composition of in the HA coating, while addition of ZrO2 to the initial HA powder resulted in significant decomposition of the final HA/ZrO2 coating and formation of other calcium phosphate phases. In turn, NIH 3T3 cells cultured in medium exposed to coated and uncoated SiC ceramics showed high re-cultivation efficiency as well as metabolic activity. The recultivation efficiency of cells was the highest for HA-coated ceramics, whereas HA/ZrO2 coating improved the recultivation efficiency of cells as compared to uncoated SiC ceramics. The GDD method allowed generating homogeneous HA coatings with no change in calcium to phosphorus ratio. In summary, porous and cytocompatible bio-SiC ceramics with bioactive coatings show a great promise in construction of light, robust, inexpensive and patient-specific bone implants for clinical application.
ASJC Scopus Sachgebiete
- Werkstoffwissenschaften (insg.)
- Allgemeine Materialwissenschaften
- Physik und Astronomie (insg.)
- Physik der kondensierten Materie
- Ingenieurwesen (insg.)
- Werkstoffmechanik
- Ingenieurwesen (insg.)
- Maschinenbau
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in: Materials Science and Engineering C, Jahrgang 68, 01.11.2016, S. 143-152.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Porous biomorphic silicon carbide ceramics coated with hydroxyapatite as prospective materials for bone implants
AU - Gryshkov, Oleksandr
AU - Klyui, Nickolai I.
AU - Temchenko, Volodymyr P.
AU - Kyselov, Vitalii S.
AU - Chatterjee, Anamika
AU - Belyaev, Alexander E.
AU - Lauterboeck, Lothar
AU - Iarmolenko, Dmytro
AU - Glasmacher, Birgit
N1 - Funding Information: The authors acknowledge the exchange program with East European Countries funded by DAAD (code # 54364768), the project # WQ20142200205 of “Thousand Talents Plan of Bureau of Foreign Experts Affairs” of the People's Republic of China. This research was in part supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, EXC 62/1) through a scholarship by the Cluster of Excellence REBIRTH. The authors would also like to express their gratitude to Prof. Dr. V . Dubok from the I. Frantsevich Institute for Problems of Material Science of the National Academy of Science of Ukraine for a kind donation of hydroxyapatite and yttrium-stabilized zirconia powders. We also acknowledge Prof. Dr. W. Wolkers as well as Prof. I. Zatovsky for FTIR and XRD measurements, respectively, including interpretation of the results.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Porous and cytocompatible silicon carbide (SiC) ceramics derived from wood precursors and coated with bioactive hydroxyapatite (HA) and HA-zirconium dioxide (HA/ZrO2) composite are materials with promising application in engineering of bone implants due to their excellent mechanical and structural properties. Biomorphic SiC ceramics have been synthesized from wood (Hornbeam, Sapele, Tilia and Pear) using a forced impregnation method. The SiC ceramics have been coated with bioactive HA and HA/ZrO2 using effective gas detonation deposition approach (GDD). The surface morphology and cytotoxicity of SiC ceramics as well as phase composition and crystallinity of deposited coatings were analyzed. It has been shown that the porosity and pore size of SiC ceramics depend on initial wood source. The XRD and FTIR studies revealed the preservation of crystal structure and phase composition of in the HA coating, while addition of ZrO2 to the initial HA powder resulted in significant decomposition of the final HA/ZrO2 coating and formation of other calcium phosphate phases. In turn, NIH 3T3 cells cultured in medium exposed to coated and uncoated SiC ceramics showed high re-cultivation efficiency as well as metabolic activity. The recultivation efficiency of cells was the highest for HA-coated ceramics, whereas HA/ZrO2 coating improved the recultivation efficiency of cells as compared to uncoated SiC ceramics. The GDD method allowed generating homogeneous HA coatings with no change in calcium to phosphorus ratio. In summary, porous and cytocompatible bio-SiC ceramics with bioactive coatings show a great promise in construction of light, robust, inexpensive and patient-specific bone implants for clinical application.
AB - Porous and cytocompatible silicon carbide (SiC) ceramics derived from wood precursors and coated with bioactive hydroxyapatite (HA) and HA-zirconium dioxide (HA/ZrO2) composite are materials with promising application in engineering of bone implants due to their excellent mechanical and structural properties. Biomorphic SiC ceramics have been synthesized from wood (Hornbeam, Sapele, Tilia and Pear) using a forced impregnation method. The SiC ceramics have been coated with bioactive HA and HA/ZrO2 using effective gas detonation deposition approach (GDD). The surface morphology and cytotoxicity of SiC ceramics as well as phase composition and crystallinity of deposited coatings were analyzed. It has been shown that the porosity and pore size of SiC ceramics depend on initial wood source. The XRD and FTIR studies revealed the preservation of crystal structure and phase composition of in the HA coating, while addition of ZrO2 to the initial HA powder resulted in significant decomposition of the final HA/ZrO2 coating and formation of other calcium phosphate phases. In turn, NIH 3T3 cells cultured in medium exposed to coated and uncoated SiC ceramics showed high re-cultivation efficiency as well as metabolic activity. The recultivation efficiency of cells was the highest for HA-coated ceramics, whereas HA/ZrO2 coating improved the recultivation efficiency of cells as compared to uncoated SiC ceramics. The GDD method allowed generating homogeneous HA coatings with no change in calcium to phosphorus ratio. In summary, porous and cytocompatible bio-SiC ceramics with bioactive coatings show a great promise in construction of light, robust, inexpensive and patient-specific bone implants for clinical application.
KW - Biomorphic SiC ceramics
KW - Bone implant
KW - Ceramic coating
KW - Cytocompatibility
KW - Gas detonation deposition
KW - Hydroxyapatite
KW - Morphology
KW - Phase composition
KW - Porosity
KW - Structure
UR - http://www.scopus.com/inward/record.url?scp=84971642427&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2016.05.113
DO - 10.1016/j.msec.2016.05.113
M3 - Article
C2 - 27524006
AN - SCOPUS:84971642427
VL - 68
SP - 143
EP - 152
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
SN - 0928-4931
ER -