TY - JOUR

T1 - Polymer/carrier composites as materials and reactors for organic synthesis

AU - Kunz, Ulrich

AU - Schönfeld, Hagen

AU - Kirschning, Andreas

AU - Solodenko, Wladimir

N1 - Funding information: Financial support by the Fonds der Chemischen Industrie, the Max-Buchner-Stiftung and Chelona is gratefully acknowledged. The presented flow-through microreactors as well as automated synthesis stations for efficient laboratory use of the reactors are available from Chelona, Hermannswerder Haus 15, D-14473 Potsdam, Germany ( www.chelona.com ).

PY - 2003/5/23

Y1 - 2003/5/23

N2 - In this work new polymer/carrier composites are described which serve as novel materials in flow-through reactors for polymer-supported organic solution-phase synthesis. Monolithic polymer/carrier columns are prepared by a new precipitation polymerization process inside the void pore volume of megaporous glass carrier materials. Chemical functionalization of the internal polymer phase with chlorosulfonic acid or trimethylamine generates small, interconnected ion-exchange resin beads with a diameter of 1-3μm which can be used for a large variety of organic syntheses. These monolithic rods are incorporated into an appropriate casing and can conveniently be operated in the flow-through mode. Important successful applications are polymer-assisted solution-phase reductions, oxidations and Horner-Emmons olefinations. Additionally, the use of these monolithic columns as catalytic microreactors and their performance in selected reactions are described.

AB - In this work new polymer/carrier composites are described which serve as novel materials in flow-through reactors for polymer-supported organic solution-phase synthesis. Monolithic polymer/carrier columns are prepared by a new precipitation polymerization process inside the void pore volume of megaporous glass carrier materials. Chemical functionalization of the internal polymer phase with chlorosulfonic acid or trimethylamine generates small, interconnected ion-exchange resin beads with a diameter of 1-3μm which can be used for a large variety of organic syntheses. These monolithic rods are incorporated into an appropriate casing and can conveniently be operated in the flow-through mode. Important successful applications are polymer-assisted solution-phase reductions, oxidations and Horner-Emmons olefinations. Additionally, the use of these monolithic columns as catalytic microreactors and their performance in selected reactions are described.

KW - Catalysts

KW - Horner-Emmons olefination

KW - Monolithic polymer/carrier microreactor

KW - Polymer-supported reagents

KW - Suzuki cross-coupling reaction

UR - http://www.scopus.com/inward/record.url?scp=0041846562&partnerID=8YFLogxK

U2 - 10.1016/S0021-9673(03)00556-9

DO - 10.1016/S0021-9673(03)00556-9

M3 - Article

C2 - 12938889

AN - SCOPUS:0041846562

VL - 1006

SP - 241

EP - 249

JO - Journal of Chromatography A

JF - Journal of Chromatography A

SN - 0021-9673

IS - 1-2

ER -