Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 934-948 |
| Seitenumfang | 15 |
| Fachzeitschrift | Journal of Biopharmaceutical Statistics |
| Jahrgang | 18 |
| Ausgabenummer | 5 |
| Frühes Online-Datum | 10 Sept. 2008 |
| Publikationsstatus | Veröffentlicht - Sept. 2008 |
Abstract
In long-term rodent carcinogenicity studies without cause of death information, poly-k-adjusted tumor rates are commonly used to assess the carcinogenic potential of a compound. Testing trend on proportions, global tests such as the Cochran-Armitage test and Williams-type test have been proposed. Here are introduced simultaneous confidence intervals and adjusted p-values for multiple contrasts on poly-k-adjusted tumor rates, based on approximation with the multivariate normal distribution. Williams-type contrasts and Dunnett-type comparisons to control are special cases of this approach. In simulation studies, the acceptable performance for finite sample sizes is demonstrated. The methods are applied to a real data example and are implemented in a package for R.
ASJC Scopus Sachgebiete
- Mathematik (insg.)
- Statistik und Wahrscheinlichkeit
- Pharmakologie, Toxikologie und Pharmazie (insg.)
- Pharmakologie
- Medizin (insg.)
- Pharmakologie (medizinische)
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in: Journal of Biopharmaceutical Statistics, Jahrgang 18, Nr. 5, 09.2008, S. 934-948.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Poly-k-trend tests for survival adjusted analysis of tumor rates formulated as approximate multiple contrast test
AU - Schaarschmidt, Frank
AU - Sill, Martin
AU - Hothorn, Ludwig A.
PY - 2008/9
Y1 - 2008/9
N2 - In long-term rodent carcinogenicity studies without cause of death information, poly-k-adjusted tumor rates are commonly used to assess the carcinogenic potential of a compound. Testing trend on proportions, global tests such as the Cochran-Armitage test and Williams-type test have been proposed. Here are introduced simultaneous confidence intervals and adjusted p-values for multiple contrasts on poly-k-adjusted tumor rates, based on approximation with the multivariate normal distribution. Williams-type contrasts and Dunnett-type comparisons to control are special cases of this approach. In simulation studies, the acceptable performance for finite sample sizes is demonstrated. The methods are applied to a real data example and are implemented in a package for R.
AB - In long-term rodent carcinogenicity studies without cause of death information, poly-k-adjusted tumor rates are commonly used to assess the carcinogenic potential of a compound. Testing trend on proportions, global tests such as the Cochran-Armitage test and Williams-type test have been proposed. Here are introduced simultaneous confidence intervals and adjusted p-values for multiple contrasts on poly-k-adjusted tumor rates, based on approximation with the multivariate normal distribution. Williams-type contrasts and Dunnett-type comparisons to control are special cases of this approach. In simulation studies, the acceptable performance for finite sample sizes is demonstrated. The methods are applied to a real data example and are implemented in a package for R.
KW - Animal carcinogenicity study
KW - Cochran-Armitage trend test
KW - Multiple contrast test
KW - Poly-3 test
UR - http://www.scopus.com/inward/record.url?scp=51649084557&partnerID=8YFLogxK
U2 - 10.1080/10543400802294285
DO - 10.1080/10543400802294285
M3 - Article
C2 - 18781526
AN - SCOPUS:51649084557
VL - 18
SP - 934
EP - 948
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
SN - 1054-3406
IS - 5
ER -