Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 6-10 |
| Seitenumfang | 5 |
| Fachzeitschrift | Phytochemistry letters |
| Jahrgang | 7 |
| Ausgabenummer | 1 |
| Publikationsstatus | Veröffentlicht - 1 Jan. 2014 |
| Extern publiziert | Ja |
Abstract
Phytochemical investigation of the aerial parts of Ligularia thomsonii has led to the isolation of three new phenylpropanoid glucosides ligularoside I (1), ligularoside II (2) and ligularoside III (3) along with nine known compounds; cinnamic acid (4), 3-phenylpropanoic acid (5), 3,4,5-trihydroxybenzoic acid (6), 4-hydroxybenzoic acid (7), p-coumaric acid (8), caffeic acid (9), 3,4-dihydroxybenzoic acid (10), kaempferol 3-O-β-d-glucopyranoside (11) and 3,5-di-O-caffeoylquinic acid (12), hitherto unreported from L. thomsonii. Their chemical structures were elucidated by spectroscopic analysis and chemical transformation. All these compounds were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 9, 10 and 12 showed significant antioxidant activity against DPPH radicals with IC50 of 19.6, 23.3 and 8.9 μm, respectively.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biotechnologie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Agrar- und Biowissenschaften (insg.)
- Agronomie und Nutzpflanzenwissenschaften
- Agrar- und Biowissenschaften (insg.)
- Pflanzenkunde
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in: Phytochemistry letters, Jahrgang 7, Nr. 1, 01.01.2014, S. 6-10.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Phytochemicals from the aerial parts of Ligularia thomsonii and their radical scavenging activity
AU - Hussain, Syed Hamid
AU - Latif, Abdul
AU - Cox, Russell J.
AU - Simpson, Thomas J.
AU - Ali, Mumtaz
AU - Arfan, Mohammad
AU - Uddin, Ghias
N1 - Funding Information: The authors acknowledge the financial support provided by the Higher Education Commission of Pakistan . We also acknowledge the School of Chemistry, University of Bristol, UK for providing bench space in their labs and access to spectroscopic instruments. Copyright: Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Phytochemical investigation of the aerial parts of Ligularia thomsonii has led to the isolation of three new phenylpropanoid glucosides ligularoside I (1), ligularoside II (2) and ligularoside III (3) along with nine known compounds; cinnamic acid (4), 3-phenylpropanoic acid (5), 3,4,5-trihydroxybenzoic acid (6), 4-hydroxybenzoic acid (7), p-coumaric acid (8), caffeic acid (9), 3,4-dihydroxybenzoic acid (10), kaempferol 3-O-β-d-glucopyranoside (11) and 3,5-di-O-caffeoylquinic acid (12), hitherto unreported from L. thomsonii. Their chemical structures were elucidated by spectroscopic analysis and chemical transformation. All these compounds were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 9, 10 and 12 showed significant antioxidant activity against DPPH radicals with IC50 of 19.6, 23.3 and 8.9 μm, respectively.
AB - Phytochemical investigation of the aerial parts of Ligularia thomsonii has led to the isolation of three new phenylpropanoid glucosides ligularoside I (1), ligularoside II (2) and ligularoside III (3) along with nine known compounds; cinnamic acid (4), 3-phenylpropanoic acid (5), 3,4,5-trihydroxybenzoic acid (6), 4-hydroxybenzoic acid (7), p-coumaric acid (8), caffeic acid (9), 3,4-dihydroxybenzoic acid (10), kaempferol 3-O-β-d-glucopyranoside (11) and 3,5-di-O-caffeoylquinic acid (12), hitherto unreported from L. thomsonii. Their chemical structures were elucidated by spectroscopic analysis and chemical transformation. All these compounds were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 9, 10 and 12 showed significant antioxidant activity against DPPH radicals with IC50 of 19.6, 23.3 and 8.9 μm, respectively.
KW - Antioxidant activity
KW - Ligularia thomsonii
KW - Phenylpropanoid glucosides
UR - http://www.scopus.com/inward/record.url?scp=84885526152&partnerID=8YFLogxK
U2 - 10.1016/j.phytol.2013.09.002
DO - 10.1016/j.phytol.2013.09.002
M3 - Article
AN - SCOPUS:84885526152
VL - 7
SP - 6
EP - 10
JO - Phytochemistry letters
JF - Phytochemistry letters
SN - 1874-3900
IS - 1
ER -