Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Christopher Heuer
  • Xin Jiang
  • Gali Ron
  • Orna Ternyak
  • Thomas Scheper
  • Janina Bahnemann
  • Ester Segal

Organisationseinheiten

Externe Organisationen

  • Technion-Israel Institute of Technology
  • Universität Augsburg
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Details

OriginalspracheEnglisch
Seiten (von - bis)1305-1308
Seitenumfang4
FachzeitschriftChemical communications
Jahrgang60
Ausgabenummer10
PublikationsstatusVeröffentlicht - 27 Dez. 2023

Abstract

We present the application of a photonic silicon chip-based optical sensor system for expeditious and phenotypic antifungal susceptibility testing. This label-free diagnostic assay optically monitors the growth of Candida auris at varying antifungal concentrations on a microwell-structured silicon chip in real-time, and antifungal susceptibility is detected within 6 h, four times faster than in the current gold standard method.

ASJC Scopus Sachgebiete

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Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris. / Heuer, Christopher; Jiang, Xin; Ron, Gali et al.
in: Chemical communications, Jahrgang 60, Nr. 10, 27.12.2023, S. 1305-1308.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Heuer C, Jiang X, Ron G, Ternyak O, Scheper T, Bahnemann J et al. Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris. Chemical communications. 2023 Dez 27;60(10):1305-1308. doi: 10.1039/d3cc04446g
Heuer, Christopher ; Jiang, Xin ; Ron, Gali et al. / Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris. in: Chemical communications. 2023 ; Jahrgang 60, Nr. 10. S. 1305-1308.
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abstract = "We present the application of a photonic silicon chip-based optical sensor system for expeditious and phenotypic antifungal susceptibility testing. This label-free diagnostic assay optically monitors the growth of Candida auris at varying antifungal concentrations on a microwell-structured silicon chip in real-time, and antifungal susceptibility is detected within 6 h, four times faster than in the current gold standard method.",
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AU - Jiang, Xin

AU - Ron, Gali

AU - Ternyak, Orna

AU - Scheper, Thomas

AU - Bahnemann, Janina

AU - Segal, Ester

N1 - Funding Information: This work was supported by the Israel Science Foundation (grant No. 2458/21). We also acknowledge funding by the German Research Foundation (DFG) via the Emmy Noether program (project ID346772917), and grant SCHE 279/32-2, as well as by the VolkswagenStiftung via the program ‘‘Niedersa¨chsisches Vorab: Research Cooperation Lower Saxony— Israel’’. The authors thank the staff of the Micro- and Nanofabrication and Printing Unit (MNFPU) at the Technion for the fabrication of the photonic silicon chips.

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