Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1622-1635 |
| Seitenumfang | 14 |
| Fachzeitschrift | Journal of Biomedical Materials Research - Part B Applied Biomaterials |
| Jahrgang | 105 |
| Ausgabenummer | 6 |
| Publikationsstatus | Veröffentlicht - 6 Mai 2016 |
Abstract
Magnesium alloys have promising mechanical and biological properties for the development of degradable implants. However, rapid implant corrosion and gas accumulations in tissue impede clinical applications. With time, the implant degradation rate is reduced by a highly biocompatible, phosphate-containing corrosion layer. To circumvent initial side effects after implantation it was attempted to develop a simple in vitro procedure to generate a similarly protective phosphate corrosion layer. To this end magnesium samples were pre-incubated in phosphate solutions. The resulting coating was well adherent during routine handling procedures. It completely suppressed the initial burst of corrosion and it reduced the average in vitro magnesium degradation rate over 56 days almost two-fold. In a small animal model phosphate coatings on magnesium implants were highly biocompatible and abrogated the appearance of gas cavities in the tissue. After implantation, the phosphate coating was replaced by a layer with an elemental composition that was highly similar to the corrosion layer that had formed on plain magnesium implants. The data demonstrate that a simple pre-treatment could improve clinically relevant properties of magnesium-based implants.
ASJC Scopus Sachgebiete
- Werkstoffwissenschaften (insg.)
- Biomaterialien
- Ingenieurwesen (insg.)
- Biomedizintechnik
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in: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Jahrgang 105, Nr. 6, 06.05.2016, S. 1622-1635.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Phosphate conversion coating reduces the degradation rate and suppresses side effects of metallic magnesium implants in an animal model
AU - Rahim, Muhammad Imran
AU - Tavares, Ana
AU - Evertz, Florian
AU - Kieke, Marc
AU - Seitz, Jan Marten
AU - Eifler, Rainer
AU - Weizbauer, Andreas
AU - Willbold, Elmar
AU - Maier, Hans Jürgen
AU - Glasmacher, Birgit
AU - Behrens, Peter
AU - Hauser, Hansjörg
AU - Mueller, Peter P.
PY - 2016/5/6
Y1 - 2016/5/6
N2 - Magnesium alloys have promising mechanical and biological properties for the development of degradable implants. However, rapid implant corrosion and gas accumulations in tissue impede clinical applications. With time, the implant degradation rate is reduced by a highly biocompatible, phosphate-containing corrosion layer. To circumvent initial side effects after implantation it was attempted to develop a simple in vitro procedure to generate a similarly protective phosphate corrosion layer. To this end magnesium samples were pre-incubated in phosphate solutions. The resulting coating was well adherent during routine handling procedures. It completely suppressed the initial burst of corrosion and it reduced the average in vitro magnesium degradation rate over 56 days almost two-fold. In a small animal model phosphate coatings on magnesium implants were highly biocompatible and abrogated the appearance of gas cavities in the tissue. After implantation, the phosphate coating was replaced by a layer with an elemental composition that was highly similar to the corrosion layer that had formed on plain magnesium implants. The data demonstrate that a simple pre-treatment could improve clinically relevant properties of magnesium-based implants.
AB - Magnesium alloys have promising mechanical and biological properties for the development of degradable implants. However, rapid implant corrosion and gas accumulations in tissue impede clinical applications. With time, the implant degradation rate is reduced by a highly biocompatible, phosphate-containing corrosion layer. To circumvent initial side effects after implantation it was attempted to develop a simple in vitro procedure to generate a similarly protective phosphate corrosion layer. To this end magnesium samples were pre-incubated in phosphate solutions. The resulting coating was well adherent during routine handling procedures. It completely suppressed the initial burst of corrosion and it reduced the average in vitro magnesium degradation rate over 56 days almost two-fold. In a small animal model phosphate coatings on magnesium implants were highly biocompatible and abrogated the appearance of gas cavities in the tissue. After implantation, the phosphate coating was replaced by a layer with an elemental composition that was highly similar to the corrosion layer that had formed on plain magnesium implants. The data demonstrate that a simple pre-treatment could improve clinically relevant properties of magnesium-based implants.
KW - animal model
KW - biodegradation
KW - coating
KW - metal alloys
KW - newberyite
UR - http://www.scopus.com/inward/record.url?scp=84966333654&partnerID=8YFLogxK
U2 - 10.1002/jbm.b.33704
DO - 10.1002/jbm.b.33704
M3 - Article
C2 - 27153508
AN - SCOPUS:84966333654
VL - 105
SP - 1622
EP - 1635
JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials
JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials
SN - 1552-4973
IS - 6
ER -