TY - JOUR

T1 - PEO–CMC blend nanofibers fabrication by electrospinning for soft tissue engineering applications

AU - Basu, Poulami

AU - Repanas, Alexandros

AU - Chatterjee, Anamika

AU - Glasmacher, Birgit

AU - NarendraKumar, U.

AU - Manjubala, I.

N1 - Funding information: The author (Poulami Basu) gratefully acknowledges partial financial support from Hochschulbüro für Internationales, Leibniz Universität Hannover, Germany. This study was funded by the Niedersächsisches Ministerium für Wissenschaft und Kultur (MWK Germany) in the joint project SynFoBiA – “Novel synthesis and formulation methods for poorly soluble drugs and sensitive biopharmaceuticals”. The authors thank Mr. Bulat Sydykov, Institute for Multiphase Processes, Leibniz Universität Hannover, Germany for his assistance in FTIR and DSC.

PY - 2017/5/15

Y1 - 2017/5/15

N2 - Polyethylene oxide (PEO) and carboxymethyl cellulose (CMC)/PEO scaffolds are fabricated by electrospinning technique for soft tissue engineering applications. Morphological analysis of the scaffolds reveals formation of stable, regular and cylindrical fibers with 3-D porous interconnected network. Polyelectrolytic nature of CMC results in the formulation of thinner CMC/PEO fibers than pure PEO fibers. All the scaffolds are thermally stable and possess appreciable tensile properties to support cells and promote their growth. The non-toxicity and the ability of the scaffolds to facilitate cell proliferation are supported by MTT assay. This study contributes a promising approach to fabricate scaffolds for possible potential applications in soft tissue engineering applications.

AB - Polyethylene oxide (PEO) and carboxymethyl cellulose (CMC)/PEO scaffolds are fabricated by electrospinning technique for soft tissue engineering applications. Morphological analysis of the scaffolds reveals formation of stable, regular and cylindrical fibers with 3-D porous interconnected network. Polyelectrolytic nature of CMC results in the formulation of thinner CMC/PEO fibers than pure PEO fibers. All the scaffolds are thermally stable and possess appreciable tensile properties to support cells and promote their growth. The non-toxicity and the ability of the scaffolds to facilitate cell proliferation are supported by MTT assay. This study contributes a promising approach to fabricate scaffolds for possible potential applications in soft tissue engineering applications.

KW - Electrospinning

KW - Fibers

KW - Polyelectrolytic nature

KW - Scaffold

KW - Tensile properties

UR - http://www.scopus.com/inward/record.url?scp=85013812210&partnerID=8YFLogxK

U2 - 10.1016/j.matlet.2017.02.065

DO - 10.1016/j.matlet.2017.02.065

M3 - Article

AN - SCOPUS:85013812210

VL - 195

SP - 10

EP - 13

JO - Materials Letters

JF - Materials Letters

SN - 0167-577X

ER -