Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 32 |
| Fachzeitschrift | Health Economics Review |
| Jahrgang | 6 |
| Ausgabenummer | 1 |
| Publikationsstatus | Veröffentlicht - 2 Aug. 2016 |
Abstract
Background: Allergic Rhinitis (AR) is a common disorder in Europe with Allergic Asthma (AA) as a frequent comorbidity. Allergy immunotherapy (AIT) is the only causal therapy of AR and AA, and can be administered as subcutaneous injections at the physician or as sublingual drops or tablets at home. The usual treatment duration is 3 years. Objective: This study aimed to elicit patient preferences to identify the AIT administration mode preferred by patients. Methods: A discrete-choice-experiment (DCE) was developed to determine how people weight different treatment options using a paper-based questionnaire from June to September 2014, including 16 study centres. Main inclusion criteria: >18 years, grass, birch and/or house dust mite AR with moderate to severe symptoms, AIT-naïve and AIT-indicated. DCE-attributes were: Administration form, number and duration of physician visits, frequency of life-threatening anaphylactic shocks, local side-effects and co-payments. Results: Two-hundred thirty-nine subjects participated, resulting in analysable 1842 choices. All attributes were significant predictors for the treatment-choice. Ranked by importance, the following first three attributes are most preferred by patients:1st Number and duration of physician visits:Fewer visits with shorter duration preferred (0.658*)2nd Frequency of life-threatening anaphylactic shocks:Lower risk of shocks preferred (0.285*)3rd Local side-effects:Preference for rash/swelling on upper arm over itching/swelling under the tongue (0.210*)(*coefficient-size represents relative importance of the attributes) Conclusion: The most important attribute is the number and duration of visits to a physician. A lower risk of life-threatening anaphylactic shocks was ranked as the second whereas co-payments and administration form play a limited role.
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in: Health Economics Review, Jahrgang 6, Nr. 1, 32, 02.08.2016.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Patient preferences in allergy immunotherapy (AIT) in Germany
T2 - a discrete-choice-experiment
AU - Damm, Kathrin
AU - Volk, Janina
AU - Horn, Andreas
AU - Allam, Jean Pierre
AU - Troensegaard-Petersen, Ninette
AU - Serup-Hansen, Niels
AU - Winkler, Thomas
AU - Thiessen, Ivonne
AU - Borchert, Kathrin
AU - Wüstenberg, Eike G.
AU - Mittendorf, Thomas
N1 - Funding Information: The study was funded by ALK-Abelló, Hørsholm, Denmark.
PY - 2016/8/2
Y1 - 2016/8/2
N2 - Background: Allergic Rhinitis (AR) is a common disorder in Europe with Allergic Asthma (AA) as a frequent comorbidity. Allergy immunotherapy (AIT) is the only causal therapy of AR and AA, and can be administered as subcutaneous injections at the physician or as sublingual drops or tablets at home. The usual treatment duration is 3 years. Objective: This study aimed to elicit patient preferences to identify the AIT administration mode preferred by patients. Methods: A discrete-choice-experiment (DCE) was developed to determine how people weight different treatment options using a paper-based questionnaire from June to September 2014, including 16 study centres. Main inclusion criteria: >18 years, grass, birch and/or house dust mite AR with moderate to severe symptoms, AIT-naïve and AIT-indicated. DCE-attributes were: Administration form, number and duration of physician visits, frequency of life-threatening anaphylactic shocks, local side-effects and co-payments. Results: Two-hundred thirty-nine subjects participated, resulting in analysable 1842 choices. All attributes were significant predictors for the treatment-choice. Ranked by importance, the following first three attributes are most preferred by patients:1st Number and duration of physician visits:Fewer visits with shorter duration preferred (0.658*)2nd Frequency of life-threatening anaphylactic shocks:Lower risk of shocks preferred (0.285*)3rd Local side-effects:Preference for rash/swelling on upper arm over itching/swelling under the tongue (0.210*)(*coefficient-size represents relative importance of the attributes) Conclusion: The most important attribute is the number and duration of visits to a physician. A lower risk of life-threatening anaphylactic shocks was ranked as the second whereas co-payments and administration form play a limited role.
AB - Background: Allergic Rhinitis (AR) is a common disorder in Europe with Allergic Asthma (AA) as a frequent comorbidity. Allergy immunotherapy (AIT) is the only causal therapy of AR and AA, and can be administered as subcutaneous injections at the physician or as sublingual drops or tablets at home. The usual treatment duration is 3 years. Objective: This study aimed to elicit patient preferences to identify the AIT administration mode preferred by patients. Methods: A discrete-choice-experiment (DCE) was developed to determine how people weight different treatment options using a paper-based questionnaire from June to September 2014, including 16 study centres. Main inclusion criteria: >18 years, grass, birch and/or house dust mite AR with moderate to severe symptoms, AIT-naïve and AIT-indicated. DCE-attributes were: Administration form, number and duration of physician visits, frequency of life-threatening anaphylactic shocks, local side-effects and co-payments. Results: Two-hundred thirty-nine subjects participated, resulting in analysable 1842 choices. All attributes were significant predictors for the treatment-choice. Ranked by importance, the following first three attributes are most preferred by patients:1st Number and duration of physician visits:Fewer visits with shorter duration preferred (0.658*)2nd Frequency of life-threatening anaphylactic shocks:Lower risk of shocks preferred (0.285*)3rd Local side-effects:Preference for rash/swelling on upper arm over itching/swelling under the tongue (0.210*)(*coefficient-size represents relative importance of the attributes) Conclusion: The most important attribute is the number and duration of visits to a physician. A lower risk of life-threatening anaphylactic shocks was ranked as the second whereas co-payments and administration form play a limited role.
KW - Allergic rhinitis
KW - Allergy immunotherapy
KW - Discrete-choice-experiment
KW - Patient preferences
KW - Sublingual immunotherapy-tablet
UR - http://www.scopus.com/inward/record.url?scp=85006226417&partnerID=8YFLogxK
U2 - 10.1186/s13561-016-0110-x
DO - 10.1186/s13561-016-0110-x
M3 - Article
AN - SCOPUS:85006226417
VL - 6
JO - Health Economics Review
JF - Health Economics Review
SN - 2191-1991
IS - 1
M1 - 32
ER -