Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | S88-S90 |
| Fachzeitschrift | Biomedizinische Technik |
| Jahrgang | 59 |
| Publikationsstatus | Veröffentlicht - 1 Okt. 2014 |
| Veranstaltung | 48th DGBMT annual conference - Hannover Dauer: 8 Okt. 2014 → 10 Okt. 2014 |
Abstract
CHANDLER-loop-systems provide a way to generate gravity-driven blood flow for in vitro-hemocompatibility testing within partially filled tube rings. There are several limitations for the use of CHANDLER-loop-systems regarding background activation and stationary flow conditions. From those limitations, rollover point for the displaced blood column, resonance frequency of the blood column, blood film transport and resulting blood-air-interface were determined crucial and thus examined. The tube material, loop diameter, tube inner diameter and filling volume were chosen according to previous experiments. Experimental flow analysis at different flow rates and tube diameters were carried out using Xrays for visualization of the phase boundary between blood and entrapped air. Rollover point was detected for a range of parameter combinations (flow rate, tube diameter, loop diameter, temperature/viscosity). An oscillating secondary motion of the blood column inside the device was observed. Resonance frequency and blood transport along the tube walls were calculated and discussed. A set of diagrams for instant experimental design were compiled from the data collected. The results of this bachelor's thesis provide guidelines for selecting a suitable operating point for CHANDLER-loopsystems adapted to particular experimental settings and objectives.
ASJC Scopus Sachgebiete
- Ingenieurwesen (insg.)
- Biomedizintechnik
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in: Biomedizinische Technik, Jahrgang 59, 01.10.2014, S. S88-S90.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Operating point analysis of a CHANDLER-loop-system for dynamic in vitro hemocompatibility testing
AU - Peschke, N.
AU - Krolitzki, B.
AU - Glasmacher, B.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - CHANDLER-loop-systems provide a way to generate gravity-driven blood flow for in vitro-hemocompatibility testing within partially filled tube rings. There are several limitations for the use of CHANDLER-loop-systems regarding background activation and stationary flow conditions. From those limitations, rollover point for the displaced blood column, resonance frequency of the blood column, blood film transport and resulting blood-air-interface were determined crucial and thus examined. The tube material, loop diameter, tube inner diameter and filling volume were chosen according to previous experiments. Experimental flow analysis at different flow rates and tube diameters were carried out using Xrays for visualization of the phase boundary between blood and entrapped air. Rollover point was detected for a range of parameter combinations (flow rate, tube diameter, loop diameter, temperature/viscosity). An oscillating secondary motion of the blood column inside the device was observed. Resonance frequency and blood transport along the tube walls were calculated and discussed. A set of diagrams for instant experimental design were compiled from the data collected. The results of this bachelor's thesis provide guidelines for selecting a suitable operating point for CHANDLER-loopsystems adapted to particular experimental settings and objectives.
AB - CHANDLER-loop-systems provide a way to generate gravity-driven blood flow for in vitro-hemocompatibility testing within partially filled tube rings. There are several limitations for the use of CHANDLER-loop-systems regarding background activation and stationary flow conditions. From those limitations, rollover point for the displaced blood column, resonance frequency of the blood column, blood film transport and resulting blood-air-interface were determined crucial and thus examined. The tube material, loop diameter, tube inner diameter and filling volume were chosen according to previous experiments. Experimental flow analysis at different flow rates and tube diameters were carried out using Xrays for visualization of the phase boundary between blood and entrapped air. Rollover point was detected for a range of parameter combinations (flow rate, tube diameter, loop diameter, temperature/viscosity). An oscillating secondary motion of the blood column inside the device was observed. Resonance frequency and blood transport along the tube walls were calculated and discussed. A set of diagrams for instant experimental design were compiled from the data collected. The results of this bachelor's thesis provide guidelines for selecting a suitable operating point for CHANDLER-loopsystems adapted to particular experimental settings and objectives.
UR - http://www.scopus.com/inward/record.url?scp=84908207096&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84908207096
VL - 59
SP - S88-S90
JO - Biomedizinische Technik
JF - Biomedizinische Technik
SN - 0013-5585
T2 - 48th DGBMT annual conference
Y2 - 8 October 2014 through 10 October 2014
ER -