TY - JOUR

T1 - Nucleotide second messengers in Streptomyces

AU - Latoscha, Andreas

AU - Wörmann, Mirka E

AU - Tschowri, Natalia

N1 - Funding information: Research in Natalia Tschowri’s lab is funded by the DFG Emmy Noether-Program (TS 325/1–1) and the DFG Priority Program SPP 1879 (TS 325/2–1). information Research in Natalia Tschowri?s lab is funded by the DFG Emmy NoetherProgram (TS 325/1?1) and the DFG Priority Program SPP 1879 (TS 325/2?1). We acknowledge Kim C. Findlay for generation of the SEMs presented in Fig. 1. Fig. 4a was originally created in a modified version by Susan Schlimpert. We thank Mark J. Buttners for sharing the panels shown in Fig. 5 with us.

PY - 2019/11

Y1 - 2019/11

N2 - Antibiotic producing Streptomyces sense and respond to environmental signals by using nucleotide second messengers, including (p)ppGpp, cAMP, c-di-GMP and c-di-AMP. As summarized in this review, these molecules are important message carriers that coordinate the complex Streptomyces morphological transition from filamentous growth to sporulation along with the secondary metabolite production. Here, we provide an overview of the enzymes that make and break these second messengers and suggest candidates for (p)ppGpp and cAMP enzymes to be studied. We highlight the target molecules that bind these signalling molecules and elaborate individual functions that they control in the context of Streptomyces development. Finally, we discuss open questions in the field, which may guide future studies in this exciting research area.

AB - Antibiotic producing Streptomyces sense and respond to environmental signals by using nucleotide second messengers, including (p)ppGpp, cAMP, c-di-GMP and c-di-AMP. As summarized in this review, these molecules are important message carriers that coordinate the complex Streptomyces morphological transition from filamentous growth to sporulation along with the secondary metabolite production. Here, we provide an overview of the enzymes that make and break these second messengers and suggest candidates for (p)ppGpp and cAMP enzymes to be studied. We highlight the target molecules that bind these signalling molecules and elaborate individual functions that they control in the context of Streptomyces development. Finally, we discuss open questions in the field, which may guide future studies in this exciting research area.

KW - Bacterial Proteins/chemistry

KW - Cyclic AMP/chemistry

KW - Dinucleoside Phosphates/chemistry

KW - Gene Expression Regulation, Bacterial

KW - Guanine Nucleotides/chemistry

KW - Protein Binding

KW - Second Messenger Systems/physiology

KW - Spores, Bacterial/growth & development

KW - Streptomyces/growth & development

KW - C-di-GMP

KW - Streptomyces

KW - C-di-AMP

KW - (p)ppGpp

KW - CAMP

UR - http://www.scopus.com/inward/record.url?scp=85074379432&partnerID=8YFLogxK

U2 - 10.1099/mic.0.000846

DO - 10.1099/mic.0.000846

M3 - Article

C2 - 31535967

VL - 165

SP - 1153

EP - 1165

JO - Microbiology

JF - Microbiology

SN - 1350-0872

IS - 11

ER -