TY - JOUR

T1 - Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces

AU - Korzhikov-Vlakh, Viktor

AU - Averianov, Ilia

AU - Sinitsyna, Ekaterina

AU - Nashchekina, Yuliya

AU - Polyakov, Dmitry

AU - Guryanov, Ivan

AU - Lavrentieva, Antonina

AU - Raddatz, Lukas

AU - Korzhikova-Vlakh, Evgenia

AU - Scheper, Thomas

AU - Tennikova, Tatiana

N1 - Funding information: This research was funded by Russian Science Foundation, grant number 14-50-00069 (05-109).

PY - 2018/12

Y1 - 2018/12

N2 - To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly("-caprolactone), as well as two types of material design, e.g., supermacroporous matrices and nanoparticles (NPs), were modified via covalent attachment of preliminary oxidized polyvinylsaccharide poly(2-deoxy-N-methacryloylamido-D-glucose) (PMAG). This polymer, being highly biocompatible and bioinspired, was used to enhance hydrophilicity of the polymer surface and to provide the elevated concentration of reactive groups required for covalent binding of bioligands of choice. The specialties of the interaction of PMAG and its preliminary formed bioconjugates with a chemically activated polyester surface were studied and thoroughly discussed. The supermacroporous materials modified with cell adhesion motifs and Arg-Gly-Asp-containing peptide (RGD-peptide) were tested in the experiments on bone tissue engineering. In turn, the NPs were modified with bioligands ("self-peptide" or camel antibodies) to control their phagocytosis that can be important, for example, for the preparation of drug delivery systems.

AB - To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly("-caprolactone), as well as two types of material design, e.g., supermacroporous matrices and nanoparticles (NPs), were modified via covalent attachment of preliminary oxidized polyvinylsaccharide poly(2-deoxy-N-methacryloylamido-D-glucose) (PMAG). This polymer, being highly biocompatible and bioinspired, was used to enhance hydrophilicity of the polymer surface and to provide the elevated concentration of reactive groups required for covalent binding of bioligands of choice. The specialties of the interaction of PMAG and its preliminary formed bioconjugates with a chemically activated polyester surface were studied and thoroughly discussed. The supermacroporous materials modified with cell adhesion motifs and Arg-Gly-Asp-containing peptide (RGD-peptide) were tested in the experiments on bone tissue engineering. In turn, the NPs were modified with bioligands ("self-peptide" or camel antibodies) to control their phagocytosis that can be important, for example, for the preparation of drug delivery systems.

KW - Biofunctionalization

KW - Bioligands

KW - Cells adhesion

KW - Nanoparticles for drug delivery

KW - PCL

KW - Phagocytosis

KW - PLA

KW - Polyesters

KW - Polyvinylsaccharide

KW - Scaffolds for bone tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=85057292339&partnerID=8YFLogxK

U2 - 10.3390/polym10121299

DO - 10.3390/polym10121299

M3 - Article

AN - SCOPUS:85057292339

VL - 10

JO - Polymers

JF - Polymers

SN - 2073-4360

IS - 12

M1 - 1299

ER -