Details
| Titel in Übersetzung | [New concepts for pressure-controlled glaucoma implants]. |
|---|---|
| Originalsprache | Deutsch |
| Seiten (von - bis) | 733-739 |
| Seitenumfang | 7 |
| Fachzeitschrift | Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft |
| Jahrgang | 110 |
| Ausgabenummer | 8 |
| Publikationsstatus | Veröffentlicht - 27 Juli 2013 |
Abstract
In industrialized countries glaucoma is one of the most common causes that leads to blindness. It is also the most common cause of irreversible blindness worldwide. In addition to local treatment of intraocular pressure and filtering glaucoma surgery, alloplastic implants are increasingly being used in glaucoma therapy. As long-term results published in the literature of commonly used implants are unsatisfactory, it seems useful to search for new concepts. In order to avoid the well-known short-term and long-term postoperative complications a pressure-controlled microstent with antiproliferative surface modifications was developed. Additionally, the functionality of such a microstent should be investigated using an animal glaucoma model. This paper describes the concept of a microstent which drains aquous humour from the anterior chamber into the suprachoroidal space. In addition, the glaucoma models described in the literature are discussed. Unfortunately, none of the methods could be reproduced permanently. First results show a correct implantation of a coated microstent with valve where the anti-proliferative effect could be demonstrated histologically. The promising results should lead to further investigations and the final goal will be the testing of the stent in the human eye.
ASJC Scopus Sachgebiete
- Medizin (insg.)
- Ophthalmologie
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in: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, Jahrgang 110, Nr. 8, 27.07.2013, S. 733-739.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Neue Konzepte für druckgesteuerte Glaukomimplantate
AU - Allemann, R.
AU - Stachs, O.
AU - Falke, K.
AU - Schmidt, W.
AU - Siewert, S.
AU - Sternberg, K.
AU - Chichkov, B.
AU - Wree, A.
AU - Schmitz, K. P.
AU - Guthoff, R. F.
PY - 2013/7/27
Y1 - 2013/7/27
N2 - In industrialized countries glaucoma is one of the most common causes that leads to blindness. It is also the most common cause of irreversible blindness worldwide. In addition to local treatment of intraocular pressure and filtering glaucoma surgery, alloplastic implants are increasingly being used in glaucoma therapy. As long-term results published in the literature of commonly used implants are unsatisfactory, it seems useful to search for new concepts. In order to avoid the well-known short-term and long-term postoperative complications a pressure-controlled microstent with antiproliferative surface modifications was developed. Additionally, the functionality of such a microstent should be investigated using an animal glaucoma model. This paper describes the concept of a microstent which drains aquous humour from the anterior chamber into the suprachoroidal space. In addition, the glaucoma models described in the literature are discussed. Unfortunately, none of the methods could be reproduced permanently. First results show a correct implantation of a coated microstent with valve where the anti-proliferative effect could be demonstrated histologically. The promising results should lead to further investigations and the final goal will be the testing of the stent in the human eye.
AB - In industrialized countries glaucoma is one of the most common causes that leads to blindness. It is also the most common cause of irreversible blindness worldwide. In addition to local treatment of intraocular pressure and filtering glaucoma surgery, alloplastic implants are increasingly being used in glaucoma therapy. As long-term results published in the literature of commonly used implants are unsatisfactory, it seems useful to search for new concepts. In order to avoid the well-known short-term and long-term postoperative complications a pressure-controlled microstent with antiproliferative surface modifications was developed. Additionally, the functionality of such a microstent should be investigated using an animal glaucoma model. This paper describes the concept of a microstent which drains aquous humour from the anterior chamber into the suprachoroidal space. In addition, the glaucoma models described in the literature are discussed. Unfortunately, none of the methods could be reproduced permanently. First results show a correct implantation of a coated microstent with valve where the anti-proliferative effect could be demonstrated histologically. The promising results should lead to further investigations and the final goal will be the testing of the stent in the human eye.
UR - http://www.scopus.com/inward/record.url?scp=84895836656&partnerID=8YFLogxK
U2 - 10.1007/s00347-013-2839-5
DO - 10.1007/s00347-013-2839-5
M3 - Artikel
C2 - 23887742
AN - SCOPUS:84895836656
VL - 110
SP - 733
EP - 739
JO - Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
JF - Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
SN - 0941-293X
IS - 8
ER -