Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 102487 |
| Seitenumfang | 7 |
| Fachzeitschrift | Current opinion in microbiology |
| Jahrgang | 79 |
| Frühes Online-Datum | 11 Mai 2024 |
| Publikationsstatus | Veröffentlicht - Juni 2024 |
Abstract
Natural products (NPs) produced by bacteria, particularly soil actinomycetes, often possess diverse bioactivities and play a crucial role in human health, agriculture, and biotechnology. Soil actinomycete genomes contain a vast number of predicted biosynthetic gene clusters (BGCs) yet to be exploited. Understanding the factors governing NP production in an ecological context and activating cryptic and silent BGCs in soil actinomycetes will provide researchers with a wealth of molecules with potential novel applications. Here, we highlight recent advances in NP discovery strategies employing ecology-inspired approaches and discuss the importance of understanding the environmental signals responsible for activation of NP production, particularly in a soil microbial community context, as well as the challenges that remain.
ASJC Scopus Sachgebiete
- Immunologie und Mikrobiologie (insg.)
- Mikrobiologie
- Medizin (insg.)
- Mikrobiologie (medizinisch)
- Medizin (insg.)
- Infektionskrankheiten
Ziele für nachhaltige Entwicklung
Zitieren
- Standard
- Harvard
- Apa
- Vancouver
- BibTex
- RIS
in: Current opinion in microbiology, Jahrgang 79, 102487, 06.2024.
Publikation: Beitrag in Fachzeitschrift › Übersichtsarbeit › Forschung › Peer-Review
}
TY - JOUR
T1 - Natural product discovery in soil actinomycetes
T2 - unlocking their potential within an ecological context
AU - Schniete, Jana K.
AU - Fernández-Martínez, Lorena T.
N1 - Publisher Copyright: © 2024 The Author(s)
PY - 2024/6
Y1 - 2024/6
N2 - Natural products (NPs) produced by bacteria, particularly soil actinomycetes, often possess diverse bioactivities and play a crucial role in human health, agriculture, and biotechnology. Soil actinomycete genomes contain a vast number of predicted biosynthetic gene clusters (BGCs) yet to be exploited. Understanding the factors governing NP production in an ecological context and activating cryptic and silent BGCs in soil actinomycetes will provide researchers with a wealth of molecules with potential novel applications. Here, we highlight recent advances in NP discovery strategies employing ecology-inspired approaches and discuss the importance of understanding the environmental signals responsible for activation of NP production, particularly in a soil microbial community context, as well as the challenges that remain.
AB - Natural products (NPs) produced by bacteria, particularly soil actinomycetes, often possess diverse bioactivities and play a crucial role in human health, agriculture, and biotechnology. Soil actinomycete genomes contain a vast number of predicted biosynthetic gene clusters (BGCs) yet to be exploited. Understanding the factors governing NP production in an ecological context and activating cryptic and silent BGCs in soil actinomycetes will provide researchers with a wealth of molecules with potential novel applications. Here, we highlight recent advances in NP discovery strategies employing ecology-inspired approaches and discuss the importance of understanding the environmental signals responsible for activation of NP production, particularly in a soil microbial community context, as well as the challenges that remain.
UR - http://www.scopus.com/inward/record.url?scp=85192500492&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2024.102487
DO - 10.1016/j.mib.2024.102487
M3 - Review article
C2 - 38733791
AN - SCOPUS:85192500492
VL - 79
JO - Current opinion in microbiology
JF - Current opinion in microbiology
SN - 1369-5274
M1 - 102487
ER -