Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 5098-5106 |
| Seitenumfang | 9 |
| Fachzeitschrift | TETRAHEDRON |
| Jahrgang | 67 |
| Ausgabenummer | 27-28 |
| Publikationsstatus | Veröffentlicht - 8 Juli 2011 |
| Extern publiziert | Ja |
Abstract
The structures of two novel metabolites, mupirocins F and F2, from extracts of the mupF mutant of Pseudomonas fluorescens were elucidated by spectroscopic methods. Methyl mupirocin F was synthesised from the triol methyl pseudomonate A by selective oxidation of the 7-hydroxyl group thus firmly establishing the structure of the natural product. Rearrangement of the densely functionalised skeleton led to unusual bicyclic and tricyclic products.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Pharmakologie, Toxikologie und Pharmazie (insg.)
- Wirkstoffforschung
- Chemie (insg.)
- Organische Chemie
Zitieren
- Standard
- Harvard
- Apa
- Vancouver
- BibTex
- RIS
in: TETRAHEDRON, Jahrgang 67, Nr. 27-28, 08.07.2011, S. 5098-5106.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Mupirocin F
T2 - Structure elucidation, synthesis and rearrangements
AU - Scott, Robert W.
AU - Murphy, Annabel C.
AU - Wu, Ji'En
AU - Hothersall, Joanne
AU - Cox, Russell J.
AU - Simpson, Thomas J.
AU - Thomas, Christopher M.
AU - Willis, Christine L.
N1 - Funding information: We are grateful to the EPSRC / BBSRC for grant E021611 (A.C.M., J.W. and J.H.) and EPSRC for a studentship (RWS) for funding this work.
PY - 2011/7/8
Y1 - 2011/7/8
N2 - The structures of two novel metabolites, mupirocins F and F2, from extracts of the mupF mutant of Pseudomonas fluorescens were elucidated by spectroscopic methods. Methyl mupirocin F was synthesised from the triol methyl pseudomonate A by selective oxidation of the 7-hydroxyl group thus firmly establishing the structure of the natural product. Rearrangement of the densely functionalised skeleton led to unusual bicyclic and tricyclic products.
AB - The structures of two novel metabolites, mupirocins F and F2, from extracts of the mupF mutant of Pseudomonas fluorescens were elucidated by spectroscopic methods. Methyl mupirocin F was synthesised from the triol methyl pseudomonate A by selective oxidation of the 7-hydroxyl group thus firmly establishing the structure of the natural product. Rearrangement of the densely functionalised skeleton led to unusual bicyclic and tricyclic products.
KW - Polyketide
KW - Rearrangements
KW - Selective oxidation
KW - Structure elucidation
UR - http://www.scopus.com/inward/record.url?scp=79958761967&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2011.05.021
DO - 10.1016/j.tet.2011.05.021
M3 - Article
AN - SCOPUS:79958761967
VL - 67
SP - 5098
EP - 5106
JO - TETRAHEDRON
JF - TETRAHEDRON
SN - 0040-4020
IS - 27-28
ER -