Multicomponent nanocrystals with anti-Stokes luminescence as contrast agents for modern imaging techniques

Publikation: Beitrag in Fachzeitschrift › Übersichtsarbeit › Forschung › Peer-Review

Autorschaft

  • A. N. Generalova
  • B. N. Chichkov
  • E. V. Khaydukov

Externe Organisationen

  • Russian Academy of Sciences (RAS)
  • Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics” of the Russian Academy of Sciences
  • Laser Zentrum Hannover e.V. (LZH)
  • Sechenov First Moscow State Medical University
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Details

OriginalspracheEnglisch
Seiten (von - bis)1-19
Seitenumfang19
FachzeitschriftAdvances in Colloid and Interface Science
Jahrgang245
PublikationsstatusVeröffentlicht - 4 Mai 2017
Extern publiziertJa

Abstract

Lanthanide-doped upconversion nanoparticles (UCNPs) have recently attracted great attention in theranostics due to their exceptional optical and physicochemical properties, which enable the design of a novel UCNP-based nanoplatform for luminescent imaging, temperature mapping, sensing, and therapy. In addition, UCNPs are considered to be ideal building blocks for development of multimodal probes for cells and whole body imaging, exploiting simple variation of host matrix, dopant ions, and surface chemistry. Modalities responsible for magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET)/single-photon emission computed tomography (SPECT) are embedded in a single UC nanocrystal, providing integrating effect over any modality alone in terms of the efficiency and sensitivity for clinical innovative diagnosis through multimodal bioimaging. In particular, we demonstrate applications of UCNPs as a new nanoplatform for optical and multimodal cancer imaging in vitro and in vivo and extend discussions to delivery of UCNP-based therapeutic agents for photodynamic and photothermal cancer treatments.

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Multicomponent nanocrystals with anti-Stokes luminescence as contrast agents for modern imaging techniques. / Generalova, A. N.; Chichkov, B. N.; Khaydukov, E. V.
in: Advances in Colloid and Interface Science, Jahrgang 245, 04.05.2017, S. 1-19.

Publikation: Beitrag in Fachzeitschrift › Übersichtsarbeit › Forschung › Peer-Review

Generalova AN, Chichkov BN, Khaydukov EV. Multicomponent nanocrystals with anti-Stokes luminescence as contrast agents for modern imaging techniques. Advances in Colloid and Interface Science. 2017 Mai 4;245:1-19. doi: 10.1016/j.cis.2017.05.006
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title = "Multicomponent nanocrystals with anti-Stokes luminescence as contrast agents for modern imaging techniques",
abstract = "Lanthanide-doped upconversion nanoparticles (UCNPs) have recently attracted great attention in theranostics due to their exceptional optical and physicochemical properties, which enable the design of a novel UCNP-based nanoplatform for luminescent imaging, temperature mapping, sensing, and therapy. In addition, UCNPs are considered to be ideal building blocks for development of multimodal probes for cells and whole body imaging, exploiting simple variation of host matrix, dopant ions, and surface chemistry. Modalities responsible for magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET)/single-photon emission computed tomography (SPECT) are embedded in a single UC nanocrystal, providing integrating effect over any modality alone in terms of the efficiency and sensitivity for clinical innovative diagnosis through multimodal bioimaging. In particular, we demonstrate applications of UCNPs as a new nanoplatform for optical and multimodal cancer imaging in vitro and in vivo and extend discussions to delivery of UCNP-based therapeutic agents for photodynamic and photothermal cancer treatments.",
keywords = "Computed tomography, Magnetic resonance imaging, Photoluminescent imaging, Positron emission tomography, Single-photon emission computed tomography, Upconversion nanoparticles",
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note = "Funding information: Chichkov B.N. would like to acknowledge Russian Science Foundation [RSCF grant ? 16-13-10528], Generalova A.N., Khaydukov E.V. acknowledge financial support from Russian Foundation for Basic Research [RFBR grant ? 17-03-01033].",
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Download

TY - JOUR

T1 - Multicomponent nanocrystals with anti-Stokes luminescence as contrast agents for modern imaging techniques

AU - Generalova, A. N.

AU - Chichkov, B. N.

AU - Khaydukov, E. V.

N1 - Funding information: Chichkov B.N. would like to acknowledge Russian Science Foundation [RSCF grant ? 16-13-10528], Generalova A.N., Khaydukov E.V. acknowledge financial support from Russian Foundation for Basic Research [RFBR grant ? 17-03-01033].

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N2 - Lanthanide-doped upconversion nanoparticles (UCNPs) have recently attracted great attention in theranostics due to their exceptional optical and physicochemical properties, which enable the design of a novel UCNP-based nanoplatform for luminescent imaging, temperature mapping, sensing, and therapy. In addition, UCNPs are considered to be ideal building blocks for development of multimodal probes for cells and whole body imaging, exploiting simple variation of host matrix, dopant ions, and surface chemistry. Modalities responsible for magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET)/single-photon emission computed tomography (SPECT) are embedded in a single UC nanocrystal, providing integrating effect over any modality alone in terms of the efficiency and sensitivity for clinical innovative diagnosis through multimodal bioimaging. In particular, we demonstrate applications of UCNPs as a new nanoplatform for optical and multimodal cancer imaging in vitro and in vivo and extend discussions to delivery of UCNP-based therapeutic agents for photodynamic and photothermal cancer treatments.

AB - Lanthanide-doped upconversion nanoparticles (UCNPs) have recently attracted great attention in theranostics due to their exceptional optical and physicochemical properties, which enable the design of a novel UCNP-based nanoplatform for luminescent imaging, temperature mapping, sensing, and therapy. In addition, UCNPs are considered to be ideal building blocks for development of multimodal probes for cells and whole body imaging, exploiting simple variation of host matrix, dopant ions, and surface chemistry. Modalities responsible for magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET)/single-photon emission computed tomography (SPECT) are embedded in a single UC nanocrystal, providing integrating effect over any modality alone in terms of the efficiency and sensitivity for clinical innovative diagnosis through multimodal bioimaging. In particular, we demonstrate applications of UCNPs as a new nanoplatform for optical and multimodal cancer imaging in vitro and in vivo and extend discussions to delivery of UCNP-based therapeutic agents for photodynamic and photothermal cancer treatments.

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KW - Magnetic resonance imaging

KW - Photoluminescent imaging

KW - Positron emission tomography

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