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| Titel in Übersetzung | Molekulare Grundlage für die Biosynthese von Elansolid: Beweise für eine einzigartige, durch ein Chinonmethid initiierte intramolekulare Diels-Alder-Cycloaddition/Makrolactonisierung |
|---|---|
| Originalsprache | Englisch |
| Seiten (von - bis) | 3882-3887 |
| Seitenumfang | 6 |
| Fachzeitschrift | Angewandte Chemie |
| Jahrgang | 50 |
| Ausgabenummer | 17 |
| Publikationsstatus | Veröffentlicht - 29 März 2011 |
Abstract
Total control: The key steps in the biosynthesis of elansolide A1, a new and structurally unique polyketide metabolite from the gliding bacterium Chitinophaga sancti, have been elucidated from feeding experiments, by analysis of the biosynthetic gene cluster, and through the synthesis of model substrates. These steps include an unprecedented dehydration reaction, an intramolecular Diels-Alder cycloaddition (IMDA), and an unusual macrolactonization.
ASJC Scopus Sachgebiete
- Chemische Verfahrenstechnik (insg.)
- Katalyse
- Chemie (insg.)
- Allgemeine Chemie
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in: Angewandte Chemie , Jahrgang 50, Nr. 17, 29.03.2011, S. 3882-3887.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Molecular basis of elansolid biosynthesis
T2 - Evidence for an unprecedented quinone methide initiated intramolecular diels-alder cycloaddition/ macrolactonization
AU - Dehn, Richard
AU - Katsuyama, Yohei
AU - Weber, Arne
AU - Gerth, Klaus
AU - Jansen, Rolf
AU - Steinmetz, Heinrich
AU - Höfle, Gerhard
AU - Müller, Rolf
AU - Kirschning, Andreas
PY - 2011/3/29
Y1 - 2011/3/29
N2 - Total control: The key steps in the biosynthesis of elansolide A1, a new and structurally unique polyketide metabolite from the gliding bacterium Chitinophaga sancti, have been elucidated from feeding experiments, by analysis of the biosynthetic gene cluster, and through the synthesis of model substrates. These steps include an unprecedented dehydration reaction, an intramolecular Diels-Alder cycloaddition (IMDA), and an unusual macrolactonization.
AB - Total control: The key steps in the biosynthesis of elansolide A1, a new and structurally unique polyketide metabolite from the gliding bacterium Chitinophaga sancti, have been elucidated from feeding experiments, by analysis of the biosynthetic gene cluster, and through the synthesis of model substrates. These steps include an unprecedented dehydration reaction, an intramolecular Diels-Alder cycloaddition (IMDA), and an unusual macrolactonization.
KW - biosynthesis
KW - intramolecular Diels-Alder reaction
KW - macrocyclizations
KW - polyketides
KW - quinone methides
UR - http://www.scopus.com/inward/record.url?scp=79954622948&partnerID=8YFLogxK
U2 - 10.1002/anie.201006880
DO - 10.1002/anie.201006880
M3 - Article
C2 - 21472917
AN - SCOPUS:79954622948
VL - 50
SP - 3882
EP - 3887
JO - Angewandte Chemie
JF - Angewandte Chemie
SN - 1433-7851
IS - 17
ER -