Modellbildung, Simulation und Regelung eines membranbegasten Zellkulturreaktors

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • R. Luttmann
  • K. H. Bellgardt
  • J. Nothnagel
  • P. Piehl
  • J. Lehmann

Externe Organisationen

  • Hochschule für Angewandte Wissenschaften Hamburg
  • Universität Bielefeld
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Details

Titel in ÜbersetzungModelling, Simulation, and control of a gas membrane cellular culture reactor
OriginalspracheDeutsch
Seiten (von - bis)66-74
Seitenumfang9
FachzeitschriftAt-Automatisierungstechnik
Jahrgang37
Ausgabenummer1-12
PublikationsstatusVeröffentlicht - Dez. 1989
Extern publiziertJa

Abstract

The cultivation of human, animal, and vegetahle cell lines in submersed methods comprises many biotechnical problems, which are not found in the cultivation of bacteria or yeasts. Especially high shear loads and foaming must be prevented in the bioreactor. In this contribution the design of an unconventional control scheme for two process-determining parameters in cellular culture technology is presented, namely the partial pressure pO2of dissolved oxygen and the concentration of free Hydrogen ions (ph value). Both variables are simultaneously controlled by adjusting a suitable gas mixture in a new type of reactor, which is fed with gas through a Hydrophobie membran without bubbles. In the first part of this contribution modelling and Simulation of the biological and engineering process, which strictly speaking must be viewed as a distributed parameter system, is presented. The secondpart then shows the theoretical analysis Simulation and realization of the chosen control scheme. It was implemented in the industrially used multi-channel Controller MICON P-200 (VDO Measurement and Control Engineering. Hannover). Both contributions are verified by experimental data.

ASJC Scopus Sachgebiete

Zitieren

Modellbildung, Simulation und Regelung eines membranbegasten Zellkulturreaktors. / Luttmann, R.; Bellgardt, K. H.; Nothnagel, J. et al.
in: At-Automatisierungstechnik, Jahrgang 37, Nr. 1-12, 12.1989, S. 66-74.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Luttmann, R, Bellgardt, KH, Nothnagel, J, Piehl, P & Lehmann, J 1989, 'Modellbildung, Simulation und Regelung eines membranbegasten Zellkulturreaktors', At-Automatisierungstechnik, Jg. 37, Nr. 1-12, S. 66-74. https://doi.org/10.1524/auto.1989.37.112.66
Luttmann, R., Bellgardt, K. H., Nothnagel, J., Piehl, P., & Lehmann, J. (1989). Modellbildung, Simulation und Regelung eines membranbegasten Zellkulturreaktors. At-Automatisierungstechnik, 37(1-12), 66-74. https://doi.org/10.1524/auto.1989.37.112.66
Luttmann R, Bellgardt KH, Nothnagel J, Piehl P, Lehmann J. Modellbildung, Simulation und Regelung eines membranbegasten Zellkulturreaktors. At-Automatisierungstechnik. 1989 Dez;37(1-12):66-74. doi: 10.1524/auto.1989.37.112.66
Luttmann, R. ; Bellgardt, K. H. ; Nothnagel, J. et al. / Modellbildung, Simulation und Regelung eines membranbegasten Zellkulturreaktors. in: At-Automatisierungstechnik. 1989 ; Jahrgang 37, Nr. 1-12. S. 66-74.
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