TY - JOUR

T1 - Mapping ethical and social aspects of biomarker research and its application in atopic dermatitis and psoriasis

T2 - a systematic review of reason

AU - Fritzsche, M. Ch

AU - Buyx, A. M.

AU - Hangel, N.

N1 - Funding information: This study has been supported by BIOMAP (Biomarkers in Atopic Dermatitis and Psoriasis) as part of the Horizon 2020 Framework Programme: a project funded by the Innovative Medicines Initiative 2 Joint Undertaking under Grant Agreement No. 821511. H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being. H2020-EU.3.1.7. - Innovative Medicines Initiative 2 (IMI2). Topic: IMI2-2017-13-02 - Genome-Environment Interactions in Inflammatory Skin Disease. Call number: H2020-JTI-IMI2-2017-13; For more information see: https://www.biomap-imi.eu/ . This study has been supported by BIOMAP (Biomarkers in Atopic Dermatitis and Psoriasis) as part of the Horizon 2020 Framework Programme: a project funded by the Innovative Medicines Initiative 2 Joint Undertaking under Grant Agreement No. 821511. H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being. H2020-EU.3.1.7. - Innovative Medicines Initiative 2 (IMI2). Topic: IMI2-2017-13-02 - Genome-Environment Interactions in Inflammatory Skin Disease. Call number: H2020-JTI-IMI2-2017-13; For more information see: https://www.biomap-imi.eu/.

PY - 2022/8

Y1 - 2022/8

N2 - Biomarker research is associated with high hopes for atopic dermatitis and psoriasis research. Although various effective treatments have been developed, many challenges remain concerning diagnostics and the development of targeted treatments, but also regarding a number of ethical and social issues. In this paper, building on a systematic literature review and review of reason, we examine the ethical and social debate on biomarker research for atopic dermatitis and psoriasis. We discuss topics such as risks and benefits of stratification of patient groups, ethical aspects of big data and advanced analytics for biomarker use in atopic dermatitis and psoriasis. Our systematic literature review of reason, based on established methodological standards, includes argument-based ethics publications and scientific literature with implicitly ethically relevant aspects. The first search of biomarker research in dermatology and adjacent fields (e.g., oncology) resulted in a large amount of literature concerning general normative aspects of biomarker research, but suggested a lack of explicit argument-based ethical literature in atopic dermatitis and psoriasis research. We, therefore, conducted a second systematic search, focusing specifically on atopic dermatitis and psoriasis biomarker research. The 43 relevant articles identified through both systematic searches were clustered into three topic groups: (i) ethical aspects of stratification and precision medicine, (ii) digital ethics and (iii) research ethics with a focus on complexity and validation. We found that compared to other fields, such as cancer research, the ethical aspects of atopic dermatitis and psoriasis are rarely explained and addressed in detail. In particular, more work is required on scientific standards, digital ethics and responsible clinical application of biomarkers for atopic dermatitis and psoriasis, patient participation and ethical implications of biomarker use for children or young people with atopic dermatitis and psoriasis. We close with suggestions on how to address the ethical and social dimension of atopic dermatitis and psoriasis research and practice more directly in future.

AB - Biomarker research is associated with high hopes for atopic dermatitis and psoriasis research. Although various effective treatments have been developed, many challenges remain concerning diagnostics and the development of targeted treatments, but also regarding a number of ethical and social issues. In this paper, building on a systematic literature review and review of reason, we examine the ethical and social debate on biomarker research for atopic dermatitis and psoriasis. We discuss topics such as risks and benefits of stratification of patient groups, ethical aspects of big data and advanced analytics for biomarker use in atopic dermatitis and psoriasis. Our systematic literature review of reason, based on established methodological standards, includes argument-based ethics publications and scientific literature with implicitly ethically relevant aspects. The first search of biomarker research in dermatology and adjacent fields (e.g., oncology) resulted in a large amount of literature concerning general normative aspects of biomarker research, but suggested a lack of explicit argument-based ethical literature in atopic dermatitis and psoriasis research. We, therefore, conducted a second systematic search, focusing specifically on atopic dermatitis and psoriasis biomarker research. The 43 relevant articles identified through both systematic searches were clustered into three topic groups: (i) ethical aspects of stratification and precision medicine, (ii) digital ethics and (iii) research ethics with a focus on complexity and validation. We found that compared to other fields, such as cancer research, the ethical aspects of atopic dermatitis and psoriasis are rarely explained and addressed in detail. In particular, more work is required on scientific standards, digital ethics and responsible clinical application of biomarkers for atopic dermatitis and psoriasis, patient participation and ethical implications of biomarker use for children or young people with atopic dermatitis and psoriasis. We close with suggestions on how to address the ethical and social dimension of atopic dermatitis and psoriasis research and practice more directly in future.

UR - http://www.scopus.com/inward/record.url?scp=85128409170&partnerID=8YFLogxK

U2 - 10.1111/jdv.18128

DO - 10.1111/jdv.18128

M3 - Review article

C2 - 35366351

AN - SCOPUS:85128409170

VL - 36

SP - 1201

EP - 1213

JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

SN - 0926-9959

IS - 8

ER -