Ion Exchange Controlled Drug Release from Polymerized Ionic Liquids

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OriginalspracheEnglisch
Aufsatznummer2000152
FachzeitschriftMacromolecular bioscience
Jahrgang20
Ausgabenummer9
PublikationsstatusVeröffentlicht - 1 Sept. 2020
Extern publiziertJa

Abstract

In this work ion functionalized hydrogels as potent drug delivery systems are presented. The ion functionalization of the hydrogel enables the retention of ionic drug molecules and thus a reduction of burst release effects. Timolol maleate in combination with polymerized anionic 3-sulfopropylmethacrylate potassium and ibuprofen combined with cationic poly-[2-(methacryloyloxy)ethyl] trimethylammonium chloride are investigated in respect to their drug release profile. The results are showing an ion exchange depending release behavior instead of a diffusion-controlled drug release as it is known from common drug delivery systems. Furthermore, the suitability of such hydrogels for standard methods for sterilization is investigated.

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Ion Exchange Controlled Drug Release from Polymerized Ionic Liquids. / Claus, Johanna; Eickner, Thomas; Grabow, Niels et al.
in: Macromolecular bioscience, Jahrgang 20, Nr. 9, 2000152, 01.09.2020.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Claus J, Eickner T, Grabow N, Kragl U, Oschatz S. Ion Exchange Controlled Drug Release from Polymerized Ionic Liquids. Macromolecular bioscience. 2020 Sep 1;20(9):2000152. doi: 10.1002/mabi.202000152
Claus, Johanna ; Eickner, Thomas ; Grabow, Niels et al. / Ion Exchange Controlled Drug Release from Polymerized Ionic Liquids. in: Macromolecular bioscience. 2020 ; Jahrgang 20, Nr. 9.
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