TY - CHAP

T1 - Introduction to cellular signal transduction

T2 - The connection between a biological system and its surroundings

AU - Boyd, Jonathan W.

AU - Neubig, Richard R.

AU - Han, Alice

AU - Prediger, Maren

PY - 2019/3/22

Y1 - 2019/3/22

N2 - Understanding the potential biological ramifications associated with altered cellular signal transduction processes is essential for research, development, testing, and evaluation of new chemical compounds for both pharmacology and toxicology. Beyond sensory perception systems that are highly innervated with direct linkages to the central nervous system, all biological interactions with the exogenous world necessitate a cellular understanding of signal transduction. This involves both extracellular and intracellular trafficking of information, which requires dynamic interplay between the plasma membrane, organelles, and cellular constituents in order to optimize the response to a changing environment. While every cellular constituent plays a role within signal transduction, some organelles are critical for both the creation and maintenance of signaling capabilities, including the mitochondria, endoplasmic reticulum, and the nucleus. Beyond their well-known functional responsibilities, these organelles also serve to integrate many disparate signals that originate from both the extracellular matrix and the cytoplasm.

AB - Understanding the potential biological ramifications associated with altered cellular signal transduction processes is essential for research, development, testing, and evaluation of new chemical compounds for both pharmacology and toxicology. Beyond sensory perception systems that are highly innervated with direct linkages to the central nervous system, all biological interactions with the exogenous world necessitate a cellular understanding of signal transduction. This involves both extracellular and intracellular trafficking of information, which requires dynamic interplay between the plasma membrane, organelles, and cellular constituents in order to optimize the response to a changing environment. While every cellular constituent plays a role within signal transduction, some organelles are critical for both the creation and maintenance of signaling capabilities, including the mitochondria, endoplasmic reticulum, and the nucleus. Beyond their well-known functional responsibilities, these organelles also serve to integrate many disparate signals that originate from both the extracellular matrix and the cytoplasm.

KW - Cellular signal transduction

KW - Endoplasmic reticulum

KW - Mitochondria

KW - Nucleus

KW - Plasma membrane

KW - Sensory perception

UR - http://www.scopus.com/inward/record.url?scp=85132688135&partnerID=8YFLogxK

U2 - 10.1002/9781119060208.ch1

DO - 10.1002/9781119060208.ch1

M3 - Contribution to book/anthology

AN - SCOPUS:85132688135

SN - 9781119060260

SP - 1

EP - 19

BT - Cellular Signal Transduction in Toxicology and Pharmacology

A2 - Boyd, Jonathan W.

A2 - Neubig, Richard R.

PB - Wiley-Blackwell

ER -