Details
| Originalsprache | Englisch |
|---|---|
| Titel des Sammelwerks | Optical Biopsy and Tissue Optics |
| Herausgeber (Verlag) | SPIE |
| Seiten | 52-60 |
| Seitenumfang | 9 |
| Publikationsstatus | Veröffentlicht - 16 Nov. 2000 |
| Veranstaltung | EOS/SPIE European Biomedical Optics Week - Amsterdam, Niederlande Dauer: 4 Juli 2000 → 8 Juli 2000 |
Publikationsreihe
| Name | Proceedings of SPIE - The International Society for Optical Engineering |
|---|---|
| Band | 4161 |
| ISSN (Print) | 0277-786X |
Abstract
In this work the dependence of the threshold energy and pulse duration for photodisruption was studied between 100 and 1500 femtoseconds using an erbium fibre laser system with subsequent chirped pulse amplification in a titanium-sapphire system. Cutting effects were analysed in animal specimens like rabbit cornea and porcine eye globes. To perform intrastromal cuts, the laser beam was guided through a computer controlled delivery system. The treated tissue was analysed by histological sections and by means of light and electron microscopy. Pressure transients were measured at the endothelium during the cutting procedure. Bubble formation and dynamics were studied using flash photography. The resulting gas bubbles were analysed to their content, and photodissociation could be noticed. As a result of these studies a set of optimised parameters for pulse duration, scanning algorithm, pulse energy and the focusing and beam delivery system could be found. The thermal damage zone in the irradiated tissue was found to be smaller than 1 μm and maximum pressure transients at the endothelium could be determined to be in the range of some hundred millibars. Moreover, performing of intrastromal cuts and creation of a lenticule for achieving a refractive effect in the eye was demonstrated. The investigations show, that fs-pulses are a very precise tool for refractive surgery.
ASJC Scopus Sachgebiete
- Werkstoffwissenschaften (insg.)
- Elektronische, optische und magnetische Materialien
- Physik und Astronomie (insg.)
- Physik der kondensierten Materie
- Informatik (insg.)
- Angewandte Informatik
- Mathematik (insg.)
- Angewandte Mathematik
- Ingenieurwesen (insg.)
- Elektrotechnik und Elektronik
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- RIS
Optical Biopsy and Tissue Optics. SPIE, 2000. S. 52-60 (Proceedings of SPIE - The International Society for Optical Engineering; Band 4161).
Publikation: Beitrag in Buch/Bericht/Sammelwerk/Konferenzband › Aufsatz in Konferenzband › Forschung › Peer-Review
}
TY - GEN
T1 - Intrastromal cutting effects in rabbit cornea using femtosecond laser pulses
AU - Heisterkamp, Alexander
AU - Ripken, Tammo
AU - Lubatschowski, Holger
AU - Welling, Herbert
AU - Lütkefels, Elke
AU - Drommer, Wolfgang
AU - Ertmer, Wolfgang
PY - 2000/11/16
Y1 - 2000/11/16
N2 - In this work the dependence of the threshold energy and pulse duration for photodisruption was studied between 100 and 1500 femtoseconds using an erbium fibre laser system with subsequent chirped pulse amplification in a titanium-sapphire system. Cutting effects were analysed in animal specimens like rabbit cornea and porcine eye globes. To perform intrastromal cuts, the laser beam was guided through a computer controlled delivery system. The treated tissue was analysed by histological sections and by means of light and electron microscopy. Pressure transients were measured at the endothelium during the cutting procedure. Bubble formation and dynamics were studied using flash photography. The resulting gas bubbles were analysed to their content, and photodissociation could be noticed. As a result of these studies a set of optimised parameters for pulse duration, scanning algorithm, pulse energy and the focusing and beam delivery system could be found. The thermal damage zone in the irradiated tissue was found to be smaller than 1 μm and maximum pressure transients at the endothelium could be determined to be in the range of some hundred millibars. Moreover, performing of intrastromal cuts and creation of a lenticule for achieving a refractive effect in the eye was demonstrated. The investigations show, that fs-pulses are a very precise tool for refractive surgery.
AB - In this work the dependence of the threshold energy and pulse duration for photodisruption was studied between 100 and 1500 femtoseconds using an erbium fibre laser system with subsequent chirped pulse amplification in a titanium-sapphire system. Cutting effects were analysed in animal specimens like rabbit cornea and porcine eye globes. To perform intrastromal cuts, the laser beam was guided through a computer controlled delivery system. The treated tissue was analysed by histological sections and by means of light and electron microscopy. Pressure transients were measured at the endothelium during the cutting procedure. Bubble formation and dynamics were studied using flash photography. The resulting gas bubbles were analysed to their content, and photodissociation could be noticed. As a result of these studies a set of optimised parameters for pulse duration, scanning algorithm, pulse energy and the focusing and beam delivery system could be found. The thermal damage zone in the irradiated tissue was found to be smaller than 1 μm and maximum pressure transients at the endothelium could be determined to be in the range of some hundred millibars. Moreover, performing of intrastromal cuts and creation of a lenticule for achieving a refractive effect in the eye was demonstrated. The investigations show, that fs-pulses are a very precise tool for refractive surgery.
KW - Intrastromal
KW - LASIK
KW - Photodisruption
KW - Refractive surgery
KW - Ultrashort laser pulses
UR - http://www.scopus.com/inward/record.url?scp=0034587030&partnerID=8YFLogxK
U2 - 10.1117/12.409337
DO - 10.1117/12.409337
M3 - Conference contribution
AN - SCOPUS:0034587030
T3 - Proceedings of SPIE - The International Society for Optical Engineering
SP - 52
EP - 60
BT - Optical Biopsy and Tissue Optics
PB - SPIE
T2 - EOS/SPIE European Biomedical Optics Week
Y2 - 4 July 2000 through 8 July 2000
ER -